While current guidelines generally recommend single endpoints for primary analyses of
confirmatory clinical trials, it is recognized that certain settings require inference on multiple …

Survival time is the primary endpoint of many randomized controlled trials, and a treatment
effect is typically quantified by the hazard ratio under the assumption of proportional …

The problem of testing multiple hypotheses using a group sequential procedure often arises
in clinical trials. We review several group sequential Holm (GSHM) type procedures …

Motivated by small-sample studies in ophthalmology and dermatology, we study the
problem of simultaneous inference for multiple endpoints in the presence of repeated …

Group sequential design (GSD) is widely used in clinical trials in which correlated tests of
multiple hypotheses are used. Multiple primary objectives resulting in tests with known …

Regulatory guidelines mandate the strong control of the familywise error rate in confirmatory
clinical trials with primary and secondary objectives. Bonferroni tests are one of the popular …

We consider multistage tests of multiple hypotheses under a flexible setting of calendar time
and information fraction, focusing on the case where there are two hypotheses under testing …

Adjustment of statistical significance levels for repeated analysis in group‐sequential trials
has been understood for some time. Adjustment accounting for testing multiple hypotheses …

The graph based approach to multiple testing is an intuitive method that enables a study
team to represent clearly, through a directed graph, its priorities for hierarchical testing of …

When simultaneously testing multiple hypotheses, the usual approach in the context of
confirmatory clinical trials is to control the familywise error rate (FWER), which bounds the …