Applications of hydrogen/deuterium exchange MS from 2012 to 2014
Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …
useful in the study of many aspects of proteins, especially the analysis of protein …
Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development–A review
Protein therapeutics have emerged as a major class of biopharmaceuticals over the past
several decades, a trend that has motivated the advancement of bioanalytical technologies …
several decades, a trend that has motivated the advancement of bioanalytical technologies …
Degradation of AMPK by a cancer-specific ubiquitin ligase
AMP-activated protein kinase (AMPK) is a master sensor and regulator of cellular energy
status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic …
status. Upon metabolic stress, AMPK suppresses anabolic and promotes catabolic …
Structure of an AMPK complex in an inactive, ATP-bound state
Adenosine monophosphate (AMP)–activated protein kinase (AMPK) regulates metabolism
in response to the cellular energy states. Under energy stress, AMP stabilizes the active …
in response to the cellular energy states. Under energy stress, AMP stabilizes the active …
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms
MF Calabrese, F Rajamohan, MS Harris, NL Caspers… - Structure, 2014 - cell.com
AMP-activated protein kinase (AMPK) is a principal metabolic regulator affecting growth and
response to cellular stress. Comprised of catalytic and regulatory subunits, each present in …
response to cellular stress. Comprised of catalytic and regulatory subunits, each present in …
Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling
The AMP-activated protein kinase (AMPK) is a metabolic stress-sensing αβγ heterotrimer
responsible for energy homeostasis, making it a therapeutic target for metabolic diseases …
responsible for energy homeostasis, making it a therapeutic target for metabolic diseases …
Reliable identification of significant differences in differential hydrogen exchange-mass spectrometry measurements using a hybrid significance testing approach
TS Hageman, DD Weis - Analytical chemistry, 2019 - ACS Publications
Differential hydrogen exchange-mass spectrometry (HX-MS) measurements are valuable for
identification of differences in the higher order structures of proteins. Typically, the data sets …
identification of differences in the higher order structures of proteins. Typically, the data sets …
HDX-MS guided drug discovery: small molecules and biopharmaceuticals
DP Marciano, V Dharmarajan, PR Griffin - Current opinion in structural …, 2014 - Elsevier
Highlights•HDX-MS has been applied to develop both small and large molecule
therapeutics.•Recent improvements to experimental platforms and software have increased …
therapeutics.•Recent improvements to experimental platforms and software have increased …
A small-molecule benzimidazole derivative that potently activates AMPK to increase glucose transport in skeletal muscle: comparison with effects of contraction and …
YC Lai, S Kviklyte, D Vertommen, L Lantier… - Biochemical …, 2014 - portlandpress.com
AMPK (AMP-activated protein kinase) is an attractive therapeutic drug target for treating
metabolic disorders. We studied the effects of an AMPK activator developed by Merck …
metabolic disorders. We studied the effects of an AMPK activator developed by Merck …
[图书][B] Hydrogen exchange mass spectrometry of proteins: fundamentals, methods, and applications
DD Weis - 2016 - books.google.com
Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the
structure and dynamics of proteins. The application of this technique is becoming …
structure and dynamics of proteins. The application of this technique is becoming …