A review on recent advances in nitrogen-containing molecules and their biological applications
The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable
source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by …
source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by …
NRF2 activation by nitrogen heterocycles: a review
Several nitrogen heterocyclic analogues have been applied to clinical practice, and about
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …
75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen …
Discovery of novel pyrazole and pyrazolo[1,5‐a]pyrimidine derivatives as cyclooxygenase inhibitors (COX‐1 and COX‐2) using molecular modeling simulation
Searching for effective and selective anti‐inflammatory agents, our study involved designing
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …
and synthesizing new pyrazole and pyrazolo [1, 5‐a] pyrimidine derivatives 4–11. The …
External electrolyte-free electrochemical one-pot cascade synthesis of 4-thiocyanato-1H-pyrazoles
WB He, SJ Zhao, JY Chen, J Jiang, X Chen, X Xu… - Chinese Chemical …, 2023 - Elsevier
ABSTRACT A practical synthetic method for 4-thiocyanato-1H-pyrazoles through the
electrochemical cascade reaction of hydrazines, 1, 3-diones and NH 4 SCN under metal …
electrochemical cascade reaction of hydrazines, 1, 3-diones and NH 4 SCN under metal …
Synthesis, biological evaluation of benzothiazole derivatives bearing a 1, 3, 4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents
XJ Zheng, CS Li, MY Cui, ZW Song, XQ Bai… - Bioorganic & Medicinal …, 2020 - Elsevier
Twenty benzothiazole derivatives bearing a 1, 3, 4-oxadiazole moiety were synthesized and
evaluated for their anti-oxidant and anti-inflammatory activities. Among these compounds …
evaluated for their anti-oxidant and anti-inflammatory activities. Among these compounds …
Design, Synthesis, Biological Evaluation, 2D-QSAR Modeling, and Molecular Docking Studies of Novel 1H-3-Indolyl Derivatives as Significant Antioxidants
Novel candidates of 3-(4-(thiophen-2-yl)-pyridin/pyran/pyrimidin/pyrazol-2-yl)-1 H-indole
derivatives (2–12) were designed by pairing the pyridine/pyrane/pyrimidine/pyrazole …
derivatives (2–12) were designed by pairing the pyridine/pyrane/pyrimidine/pyrazole …
Synthesis, spectroscopic characterization, reactive properties by DFT calculations, molecular dynamics simulations and biological evaluation of Schiff bases tethered …
The synthesis, spectroscopic characterization, reactivity study and evaluation of antioxidant
and α-glucosidase inhibitory activities of two Schiff bases containing 1, 2, 4-triazole and …
and α-glucosidase inhibitory activities of two Schiff bases containing 1, 2, 4-triazole and …
[PDF][PDF] Antimicrobial evaluation and molecular properties prediction of pyrazolines incorporating benzofuran and pyrazole moieties
MA Elsherif, AS Hassan, GO Moustafa… - Journal of Applied …, 2020 - japsonline.com
Abstract A series of chalcones 3–5, 1H-pyrazolines 6–8, N-phenylpyrazolines 9–11, and N-
acetylpyrazolines 12–14 incorporating benzofuran and pyrazole moieties were synthesized …
acetylpyrazolines 12–14 incorporating benzofuran and pyrazole moieties were synthesized …
[HTML][HTML] Recent advances and SAR study of 2-substituted benzothiazole scaffold based potent chemotherapeutic agents
In recent times cancer has become one of the leading causes of death. Globally around 11
million deaths are reported every year due to cancer. Some clinically approved anticancer …
million deaths are reported every year due to cancer. Some clinically approved anticancer …
Synthesis of steroidal dihydropyrazole derivatives using green ZnO NPs and evaluation of their anticancer and antioxidant activity
Abstract Zinc oxide nanoparticles (ZnO NPs) were synthesized by a green method using
Azadirachta indica leaf extract. The structure of the prepared ZnO (NPs) were characterized …
Azadirachta indica leaf extract. The structure of the prepared ZnO (NPs) were characterized …