Hypoxia a hallmark of solid tumors makes hypoxic cells radioresistant. On the other
hand, DNA, the main target of anticancer therapy, is not sensitive to the near UV photons …

In this work, a set of new potential radiation sensitizers (4-substituted Z-bases: 4XZ, X= F, Cl,
Br, and I) are designed based on the artificial 6-amino-5-nitro-3-(1′-β-D-2 …

The TYT and TXT trimeric oligonucleotides, where X stands for a native nucleobase, T
(thymine), C (cytosine), A (adenine), or G (guanine), and Y indicates a brominated analogue …

Hypoxia, a hallmark of solid tumors, which account for ca. 80% of cancer cases, makes the
cancer cells resistant toward ionizing radiation and as a consequence to radiotherapy, one …

We investigate the proton transfer reaction of radiosensitizing drugs 5-substituted thymine-
adenine (5XT-A, X= Br, OCN) in water solutions through the density functional theory (DFT) …

Tumor hypoxia hampers radiotherapy efficacy, necessitating radiosensitizers. Substituted
nucleobases offer advantages as radiosensitizers. They can be incorporated into DNA with …

Previous density functional theory (DFT) studies on 6-brominated pyrimidine nucleosides
suggest that 6-iodo-2′-deoxyuridine (6IdU) should act as a better radiosensitizer than its 5 …

Experimental studies showed that high energy radiation induced base release and DNA
backbone breaks mainly occur at the neighboring 5′ nucleotide when a single-stranded …

Ultraviolet radiation induced damage to DNA/RNA can lead to chemical modifications to the
nucleosides, and understanding the excited states involved is the key to reveal the …

Halogen-substituted pyrimidines, such as 5-bromouracil and 5-iodouracil, have been used
as radio therapeutic (RT) agents in cancer treatment. The radiosensitizing activity of 5 …