TGF-β modulated pathways in colorectal cancer: new potential therapeutic opportunities

M Fasano, M Pirozzi, CC Miceli… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with 20%
of patients presenting with metastatic disease at diagnosis. TGF-β signaling plays a crucial …

Metronomic chemotherapy: anti-tumor pathways and combination with immune checkpoint inhibitors

E Muraro, L Vinante, E Fratta, A Bearz, D Höfler… - Cancers, 2023 - mdpi.com
Simple Summary Metronomic chemotherapy, a continuous administration of a lowered dose
of drugs without long breaks, is currently considered an alternative approach for the …

Green synthesis of Zn-doped TIO2 nanoparticles from Zanthoxylum armatum

A Batool, A Azizullah, K Ullah, S Shad, FU Khan… - BMC Plant …, 2024 - Springer
Green synthesis is an easy, safe, and environmentally beneficial nanoparticle creation
method. It is a great challenge to simultaneously improve the capping and stabilizing agent …

The role of hypoxia-inducible factor-1 alpha in renal disease

H Liu, Y Li, J Xiong - Molecules, 2022 - mdpi.com
Partial pressure of oxygen (pO2) in the kidney is maintained at a relatively stable level by a
unique and complex functional interplay between renal blood flow, glomerular filtration rate …

Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3 to the single‐stranded DNA‐binding protein 1 (SSBP1) promoter region

KD Wang, ML Zhu, CJ Qin, RF Dong… - British Journal of …, 2023 - Wiley Online Library
Abstract Background and Purpose Osteosarcoma, a primary malignant bone tumour
prevalent among adolescents and young adults, remains a considerable challenge despite …

Lead/drug discovery from natural resources

Z Xu, B Eichler, EA Klausner, J Duffy-Matzner, W Zheng - Molecules, 2022 - mdpi.com
Natural products and their derivatives have been shown to be effective drug candidates
against various diseases for many years. Over a long period of time, nature has produced an …

Utilization of kinase inhibitors as novel therapeutic drug targets: A review

S Nishal, V Jhawat, S Gupta, P Phaugat - Oncology research, 2023 - pmc.ncbi.nlm.nih.gov
Kinase inhibitors are a significant and continuously developing division of target
therapeutics. The drug discovery and improvement efforts have examined numerous …

Novel molecular targets for immune surveillance of hepatocellular carcinoma

P Guerra, A Martini, P Pontisso, P Angeli - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular Carcinoma (HCC) is a common and aggressive cancer
with limited treatment options. Approximately half of all patients with HCC receive systemic …

JI017 Induces cell autophagy and apoptosis via elevated levels of reactive oxygen species in human lung cancer cells

JM Ku, MJ Kim, YJ Choi, SY Lee, JY Im, YK Jo… - International Journal of …, 2023 - mdpi.com
Lung cancer is one of the most common malignant tumors and a leading cause of cancer-
related death in the worldwide. Various anticancer drugs, such as cisplatin and pemetrexed …

Molecular targeted therapies in metastatic prostate cancer: recent advances and future challenges

C Sorrentino, E Di Carlo - Cancers, 2023 - mdpi.com
Simple Summary Recent studies have highlighted the importance of molecular targeted
therapies in metastatic castration-resistant prostate cancer. These therapies, which aim to …