P Bernardi, M Carraro, G Lippe - The FEBS journal, 2022 - Wiley Online Library
Major progress has been made in defining the basis of the mitochondrial permeability transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …
DJ Robichaux, M Harata, E Murphy, J Karch - Journal of molecular and …, 2023 - Elsevier
Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is …
P Wang, S Xu, J Xu, Y Xin, Y Lu, H Zhang, B Zhou… - Circulation, 2022 - Am Heart Assoc
Background: Calcium (Ca2+) is a key regulator of energy metabolism. Impaired Ca2+ homeostasis damages mitochondria, causing cardiomyocyte death, pathological …
N Mnatsakanyan, MC Llaguno, Y Yang, Y Yan… - Nature …, 2019 - nature.com
Purified mitochondrial ATP synthase has been shown to form Ca2+-activated, large conductance channel activity similar to that of mitochondrial megachannel (MMC) or …
BR Alevriadou, A Patel, M Noble… - … of Physiology-Cell …, 2021 - journals.physiology.org
Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …
Mitochondrial permeability transition, as the consequence of opening of a mitochondrial permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …
E Murphy, JC Liu - Cardiovascular Research, 2023 - academic.oup.com
Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with∼ 30–40% of the cell volume being composed of mitochondria. Mitochondria are well established as …
GA Porter Jr, G Beutner - Biomolecules, 2018 - mdpi.com
Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of action remains a mystery. It is well known for regulating mitochondrial function and coupling …
Z Luo, J Yao, Z Wang, J Xu - Journal of Translational Medicine, 2023 - Springer
Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the existing ones, playing critical roles in physiological and pathological processes such as …