Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus,
cardiomyocyte death as occurs during myocardial infarction has very detrimental …

Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

Mitochondrial permeability transition pore (mPTP)-dependent cell death is a form of necrotic
cell death that is driven by mitochondrial dysfunction by the opening of the mPTP and is …

Background: Calcium (Ca2+) is a key regulator of energy metabolism. Impaired Ca2+
homeostasis damages mitochondria, causing cardiomyocyte death, pathological …

Purified mitochondrial ATP synthase has been shown to form Ca2+-activated, large
conductance channel activity similar to that of mitochondrial megachannel (MMC) or …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Mitochondrial permeability transition, as the consequence of opening of a mitochondrial
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …

Cardiomyocytes are one of the most mitochondria-rich cell types in the body, with∼ 30–40%
of the cell volume being composed of mitochondria. Mitochondria are well established as …

Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of
action remains a mystery. It is well known for regulating mitochondrial function and coupling …

Endothelial cells (ECs) angiogenesis is the process of sprouting new vessels from the
existing ones, playing critical roles in physiological and pathological processes such as …