Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Gelatin is a promising material as scaffold with therapeutic and regenerative characteristics
due to its chemical similarities to the extracellular matrix (ECM) in the native tissues …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Photo-crosslinkable hydrogels have recently attracted significant scientific interest. Their
properties can be manipulated in a spatiotemporal manner through exposure to light to …

Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

We review the emergence of the new field of organ-on-a-chip (OOAC) engineering, from the
parent fields of tissue engineering and microfluidics. We place into perspective the tools and …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Purpose: Both cardiomyocytes and cardiac fibroblasts (CF) play essential roles in cardiac
development, function, and remodeling. Properties of 3D co-cultures are incompletely …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

While interstitial fibrosis plays a significant role in heart failure, our understanding of disease
progression in humans is limited. To address this limitation, we have engineered a cardiac …