Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Epithelial organoids, such as those derived from stem cells of the intestine, have great
potential for modelling tissue and disease biology,,–. However, the approaches that are …

Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long …

Microfluidic organ-on-a-chip models of human intestine have been developed and used to
study intestinal physiology and pathophysiology. In this article, we review this field and …

The first microfluidic microphysiological systems (MPS) entered the academic scene more
than 15 years ago and were considered an enabling technology to human in vitro (patho) …

Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …

The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Mounting evidence from metagenomic analyses suggests that a state of pathological
microbial imbalance or dysbiosis is prevalent in the gut of patients with colorectal cancer …

With recent progress in modeling liver organogenesis and regeneration, the lack of
vasculature is becoming the bottleneck in progressing our ability to model human hepatic …