Challenges and recent progress in oral drug delivery systems for biopharmaceuticals

B Homayun, X Lin, HJ Choi - Pharmaceutics, 2019 - mdpi.com
Routes of drug administration and the corresponding physicochemical characteristics of a
given route play significant roles in therapeutic efficacy and short term/long term biological …

Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: A review

DJ McClements - Advances in colloid and interface science, 2018 - Elsevier
There are many examples of bioactive proteins and peptides that would benefit from oral
delivery through functional foods, supplements, or medical foods, including hormones …

Current state and challenges in developing oral vaccines

JEV Ramirez, LA Sharpe, NA Peppas - Advanced drug delivery reviews, 2017 - Elsevier
While vaccination remains the most cost effective strategy for disease prevention,
communicable diseases persist as the second leading cause of death worldwide. There is a …

Platforms for production of protein-based vaccines: from classical to next-generation strategies

R Cid, J Bolívar - Biomolecules, 2021 - mdpi.com
To date, vaccination has become one of the most effective strategies to control and reduce
infectious diseases, preventing millions of deaths worldwide. The earliest vaccines were …

Structure-function and application of plant lectins in disease biology and immunity

A Mishra, A Behura, S Mawatwal, A Kumar… - Food and Chemical …, 2019 - Elsevier
Lectins are proteins with a high degree of stereospecificity to recognize various sugar
structures and form reversible linkages upon interaction with glyco-conjugate complexes …

Recent progress in mucosal vaccine development: potential and limitations

N Lycke - Nature reviews immunology, 2012 - nature.com
Most pathogens access the body through the mucosal membranes. Therefore, effective
vaccines that protect at these sites are much needed. However, despite early success with …

Overcoming the intestinal barrier: a look into targeting approaches for improved oral drug delivery systems

Y Xu, N Shrestha, V Préat, A Beloqui - Journal of controlled release, 2020 - Elsevier
Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …

[HTML][HTML] Status of vaccine research and development for Shigella

S Mani, T Wierzba, RI Walker - Vaccine, 2016 - Elsevier
Shigella are gram-negative bacteria that cause severe diarrhea and dysentery. In 2013,
Shigella infections caused an estimated 34,400 deaths in children less than five years old …

Spatiotemporal manipulation metal–organic frameworks as oral drug delivery systems for precision medicine

Z Wang, J Chen, R Gao, L Jiang, G Zhang… - Coordination Chemistry …, 2024 - Elsevier
Oral drug administration is the preferred method for delivering medications due to its safety,
ease of ingestion, high patient compliance, absence of pain, and adaptability to a wide …

Mucosal vaccines and technology

A Miquel-Clopés, EG Bentley, JP Stewart… - Clinical & …, 2019 - academic.oup.com
There is an urgent and unmet need to develop effective vaccines to reduce the global
burden of infectious disease in both animals and humans, and in particular for the majority of …