[HTML][HTML] Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
Advancing the use of genome-wide association studies for drug repurposing
Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …
complex diseases, which are broadly expected to lead to the identification of new drug …
A cross-population atlas of genetic associations for 220 human phenotypes
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
[HTML][HTML] Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke—the second leading cause of
death worldwide—were conducted predominantly in populations of European ancestry …
death worldwide—were conducted predominantly in populations of European ancestry …
Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …
practice. Progress in high-throughput technologies has provided new opportunities to …
Large-scale meta-analysis across East Asian and European populations updated genetic architecture and variant-driven biology of rheumatoid arthritis, identifying 11 …
Objectives Nearly 110 susceptibility loci for rheumatoid arthritis (RA) with modest effect sizes
have been identified by population-based genetic association studies, suggesting a large …
have been identified by population-based genetic association studies, suggesting a large …
[HTML][HTML] Cerebral small vessel disease genomics and its implications across the lifespan
M Sargurupremraj, H Suzuki, X Jian… - Nature …, 2020 - nature.com
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …
[HTML][HTML] The current landscape of psoriasis genetics in 2020
Psoriasis is an immune-mediated disease associated with skin and joint inflammation that
affects large proportions of populations worldwide. It is a heritable disease: individuals' …
affects large proportions of populations worldwide. It is a heritable disease: individuals' …
[HTML][HTML] Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease
Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia …
Stroke genetics: discovery, insight into mechanisms, and clinical perspectives
S Debette, HS Markus - Circulation Research, 2022 - Am Heart Assoc
Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …
condition. In this review, we provide an overview of the current knowledge on monogenic …