[HTML][HTML] Macrophage polarization: different gene signatures in M1 (LPS+) vs. classically and M2 (LPS–) vs. alternatively activated macrophages
M Orecchioni, Y Ghosheh, AB Pramod… - Frontiers in …, 2019 - frontiersin.org
Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue
macrophages are seeded in the early embryo before definitive hematopoiesis is …
macrophages are seeded in the early embryo before definitive hematopoiesis is …
[HTML][HTML] Multi-omics approaches to disease
High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …
genotyping arrays enabled large-scale genome-wide association studies and methods for …
[HTML][HTML] Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …
about the mechanisms that influence these traits. Combining data for up to 703,901 …
Where are the disease-associated eQTLs?
Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …
have detectable effects on gene expression. One explanation could be that we have not …
A road map for understanding molecular and genetic determinants of osteoporosis
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure
Tissue-tissue communication by endocrine factors is a vital mechanism for physiologic
homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort …
homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort …
RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and …
D Karunakaran, MA Nguyen, M Geoffrion, D Vreeken… - Circulation, 2021 - Am Heart Assoc
Background: Chronic activation of the innate immune system drives inflammation and
contributes directly to atherosclerosis. We previously showed that macrophages in the …
contributes directly to atherosclerosis. We previously showed that macrophages in the …
Inter-organ cross-talk in metabolic syndrome
C Priest, P Tontonoz - Nature Metabolism, 2019 - nature.com
Maintenance of systemic homeostasis and the response to nutritional and environmental
challenges require the coordination of multiple organs and tissues. To respond to various …
challenges require the coordination of multiple organs and tissues. To respond to various …
Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms
The mammalian circadian clock, expressed throughout the brain and body, controls daily
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
metabolic homeostasis. Clock function in peripheral tissues is required, but not sufficient, for …
Mouse models of atherosclerosis in translational research
Atherosclerotic cardiovascular disease (CVD), the major cause of premature human
mortality, is a chronic and progressive metabolic and inflammatory disease in large-and …
mortality, is a chronic and progressive metabolic and inflammatory disease in large-and …