The precise temporal and spatial coordination of histone lysine methylation dynamics across
the epigenome regulates virtually all DNA-templated processes. A large number of histone …

How can we treat cancer more effectively? Traditionally, tumours from the same anatomical
site are treated as one tumour entity. This concept has been challenged by recent …

Lineage-ambiguous leukemias are high-risk malignancies of poorly understood genetic
basis. Here, we describe a distinct subgroup of acute leukemia with expression of myeloid, T …

Much controversy surrounds the cell-of-origin of mutant K-Ras (K-RasG12D)–induced lung
adenocarcinoma. To shed light on this issue, we have used technology that enables us to …

High-throughput sequencing (HTS) of lymphoid receptor genes is an emerging technology
that can comprehensively assess the diversity of the immune system. Here, we applied HTS …

In the past decade important progress has been made in our understanding of the
epigenetic regulatory machinery. It has become clear that genetic aberrations in multiple …

The most common pediatric malignancy is acute lymphoblastic leukemia (ALL), of which T‐
cell ALL (T‐ALL) comprises 10–15% of cases. T‐ALL arises in the thymus from an immature …

With the genetic portraits of all major human malignancies now available, we next face the
challenge of characterizing the function of mutated genes, their downstream targets …

Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …

Lung cancer is a devastating disease and a major therapeutic burden with poor survival
rates. It is responsible for 30% of all cancer deaths. Lung cancer is strongly associated with …