Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key
antecedent to the development of CV disease (CVD). Arterial dysfunction with aging is …

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …

The goal of this study is to identify a signature of bioenergetic and functional markers in the
muscles of individuals with Parkinson's disease (PD). Quantitative physiological properties …

Advancing age and many disease states are associated with declines in nicotinamide
adenine dinucleotide (NAD+) levels. Preclinical studies suggest that boosting NAD+ …

The development of age-related cardiovascular (CV) dysfunction increases the risk of CV
disease as well as other chronic age-associated disorders, including chronic kidney …

Endovascular interventions often fail due to restenosis, primarily caused by smooth muscle
cell (SMC) proliferation, leading to intimal hyperplasia (IH). Current strategies to prevent …

The role of nicotinamide adenine dinucleotide (NAD+) in ageing has emerged as a critical
factor in understanding links to a wide range of chronic diseases. Depletion of NAD+, a …

Aging is the greatest non-modifiable risk factor for most diseases, including cardiovascular
diseases (CVD), which remain the leading cause of mortality worldwide. Robust evidence …

Hypertension is among the most prevalent diagnoses across the world and increases the
risk of many serious health problems, such as stroke, heart disease, and kidney disease …

NAD is an essential co-factor for cellular energy metabolism and multiple other processes.
Systemic NAD+ deficiency has been implicated in skeletal deformities during development …