The glutathione peroxidase family: Discoveries and mechanism

L Flohé, S Toppo, L Orian - Free Radical Biology and Medicine, 2022 - Elsevier
The discoveries leading to our present understanding of the glutathione peroxidases (GPxs)
are recalled. The cytosolic GPx, now GPx1, was first described by Mills in 1957 and claimed …

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling

A Perkins, KJ Nelson, D Parsonage, LB Poole… - Trends in biochemical …, 2015 - cell.com
Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

Monitoring the fluctuation of hydrogen peroxide in diabetes and its complications with a novel near-infrared fluorescent probe

WX Wang, WL Jiang, GJ Mao, M Tan, J Fei… - Analytical …, 2021 - ACS Publications
Diabetes is one of the metabolic diseases marked by hyperglycemia and is often
accompanied by the occurrence of some complications. As a biomarker of oxidative stress …

Molecular interactions in organic nanoparticles for phototheranostic applications

KK Ng, G Zheng - Chemical reviews, 2015 - ACS Publications
Optical and photonic technologies play an important role in human progress. The bending of
light to our will has not only enabled our biological self-discovery, but has also allowed us to …

[HTML][HTML] The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke

S Kim, W Lee, H Jo, SK Sonn, SJ Jeong, S Seo, J Suh… - Redox biology, 2022 - Elsevier
Ischemic stroke is the leading cause of immortal disability and death worldwide. For
treatment in the acute phase, it is necessary to control excessive reactive oxygen species …

Biological and physiological role of reactive oxygen species–the good, the bad and the ugly

L Zuo, T Zhou, BK Pannell, AC Ziegler… - Acta …, 2015 - Wiley Online Library
Reactive oxygen species (ROS) are chemically reactive molecules that are naturally
produced within biological systems. Research has focused extensively on revealing the …

[HTML][HTML] Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

SA Mason, AJ Trewin, L Parker, GD Wadley - Redox biology, 2020 - Elsevier
Antioxidant supplements are commonly consumed by endurance athletes to minimize
exercise-induced oxidative stress, with the intention of enhancing recovery and improving …

How mitochondria produce reactive oxygen species

MP Murphy - Biochemical journal, 2009 - portlandpress.com
The production of ROS (reactive oxygen species) by mammalian mitochondria is important
because it underlies oxidative damage in many pathologies and contributes to retrograde …

Reactive oxygen species: Physiological and physiopathological effects on synaptic plasticity: Supplementary issue: Brain plasticity and repair

TF Beckhauser, J Francis-Oliveira… - Journal of …, 2016 - journals.sagepub.com
In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

The Response to Heat Shock and Oxidative Stress in Saccharomyces cerevisiae

KA Morano, CM Grant, WS Moye-Rowley - Genetics, 2012 - academic.oup.com
A common need for microbial cells is the ability to respond to potentially toxic environmental
insults. Here we review the progress in understanding the response of the yeast …