The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
PTEN function: the long and the short of it
BD Hopkins, C Hodakoski, D Barrows… - Trends in biochemical …, 2014 - cell.com
Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a phosphatase that
is frequently altered in cancer. PTEN has phosphatase-dependent and-independent roles …
is frequently altered in cancer. PTEN has phosphatase-dependent and-independent roles …
Engineered exosomes as vehicles for biologically active proteins
Exosomes represent an attractive vehicle for the delivery of biomolecules. However,
mechanisms for loading functional molecules into exosomes are relatively unexplored. Here …
mechanisms for loading functional molecules into exosomes are relatively unexplored. Here …
Identification of important modules and biomarkers in breast cancer based on WGCNA
Z Tian, W He, J Tang, X Liao, Q Yang… - OncoTargets and …, 2020 - Taylor & Francis
Introduction Breast cancer (BRCA) has the highest incidence among female malignancies,
and the prognosis for these patients remains poor. Materials and Methods In this study, core …
and the prognosis for these patients remains poor. Materials and Methods In this study, core …
Structural biology and regulation of protein import into the nucleus
Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …
their functions. Understanding how these nuclear proteins are transported through the …
[HTML][HTML] Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects
M Scheffner, S Kumar - Biochimica et Biophysica Acta (BBA)-Molecular …, 2014 - Elsevier
Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …
Overview and update on methods for cargo loading into extracellular vesicles
The enormous library of pharmaceutical compounds presents endless research avenues.
However, several factors limit the therapeutic potential of these drugs, such as drug …
However, several factors limit the therapeutic potential of these drugs, such as drug …
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells
Exosomes are microvesicles of endosomal origin that are secreted, and their contents
(proteins, lipids, DNA, or microRNAs) can alter the physiological states of recipient cells. We …
(proteins, lipids, DNA, or microRNAs) can alter the physiological states of recipient cells. We …
Regulating the human HECT E3 ligases
J Sluimer, B Distel - Cellular and molecular life sciences, 2018 - Springer
Ubiquitination, the covalent attachment of ubiquitin to proteins, by E3 ligases of the HECT
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …
PTEN is a protein tyrosine phosphatase for IRS1
Y Shi, J Wang, S Chandarlapaty, J Cross… - Nature structural & …, 2014 - nature.com
The biological function of the PTEN tumor suppressor is mainly attributed to its lipid
phosphatase activity. This study demonstrates that mammalian PTEN is a protein tyrosine …
phosphatase activity. This study demonstrates that mammalian PTEN is a protein tyrosine …