Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications

F Zhang, RI Lau, Q Liu, Q Su, FKL Chan… - Nature Reviews …, 2023 - nature.com
The gastrointestinal tract is involved in coronavirus disease 2019 (COVID-19) caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The gut microbiota has …

Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?

TC Theoharides - Molecular Neurobiology, 2022 - Springer
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells
and results in acute symptoms involving especially the lungs known as COVID-19. However …

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

K Yin, MJ Peluso, X Luo, R Thomas, MG Shin… - Nature …, 2024 - nature.com
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …

Long COVID and the cardiovascular system—elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint …

M Gyöngyösi, P Alcaide, FW Asselbergs… - Cardiovascular …, 2023 - academic.oup.com
Long COVID has become a world-wide, non-communicable epidemic, caused by long-
lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection …

SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2

KM Littlefield, RO Watson, JM Schneider… - PLoS …, 2022 - journals.plos.org
As of January 2022, at least 60 million individuals are estimated to develop post-acute
sequelae of SARS-CoV-2 (PASC) after infection with severe acute respiratory syndrome …

Cellular and molecular biomarkers of long COVID: a scoping review

E Espín, C Yang, CP Shannon, S Assadian, D He… - …, 2023 - thelancet.com
Summary Background Long-COVID (LC) encompasses diverse symptoms lasting months
after the initial SARS-CoV-2 infection. Symptoms can be debilitating and affect the quality of …

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

DM Altmann, CJ Reynolds, G Joy, AD Otter… - Nature …, 2023 - nature.com
Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in
Long Covid is whether there is a contributory role of abnormal immunity during acute …

COVID-19 vaccination for the prevention and treatment of long COVID: A systematic review and meta-analysis

F Ceban, D Kulzhabayeva, NB Rodrigues… - Brain, behavior, and …, 2023 - Elsevier
Empirical evidence addressing the association between SARS-CoV-2 vaccination and long
COVID would guide public health priorities and inform personal health decisions. Herein …

Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response

A Santa Cruz, A Mendes-Frias… - Nature …, 2023 - nature.com
Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2
condition (PASC) that persists for months after infection. Here we evaluate the immune …

The role of immune activation and antigen persistence in acute and long COVID

S Opsteen, JK Files, T Fram… - Journal of Investigative …, 2023 - journals.sagepub.com
In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered the
global coronavirus disease 2019 (COVID-19) pandemic. Although most infections cause a …