The role of macrophages in HIV-1 persistence and pathogenesis
Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
A CRISPR-Cas Cure for HIV/AIDS
M Hussein, MA Molina, B Berkhout… - International journal of …, 2023 - mdpi.com
Human immunodeficiency virus (HIV) infections and HIV-induced acquired
immunodeficiency syndrome (AIDS) continue to represent a global health burden. There is …
immunodeficiency syndrome (AIDS) continue to represent a global health burden. There is …
HIV replication and latency in monocytes and macrophages
RT Veenhuis, CM Abreu, EN Shirk, L Gama… - Seminars in …, 2021 - Elsevier
The relevance of monocyte and macrophage reservoirs in virally suppressed people with
HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a …
HIV (vsPWH) has previously been debatable. Macrophages were assumed to have a …
HIV-1 capsid core: A bullet to the heart of the target cell
E Toccafondi, D Lener, M Negroni - Frontiers in Microbiology, 2021 - frontiersin.org
The first step of the intracellular phase of retroviral infection is the release of the viral capsid
core in the cytoplasm. This structure contains the viral genetic material that will be reverse …
core in the cytoplasm. This structure contains the viral genetic material that will be reverse …
MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus
XW Meng, ZL Cheng, ZY Lu, YN Tan, XY Jia… - Frontiers in …, 2022 - frontiersin.org
Background Systemic lupus erythematosus (SLE) is an autoimmune disease that involves
multiple organs. However, the current SLE-related biomarkers still lack sufficient sensitivity …
multiple organs. However, the current SLE-related biomarkers still lack sufficient sensitivity …
Interplay between intrinsic and innate immunity during HIV infection
Restriction factors are antiviral components of intrinsic immunity which constitute a first line
of defense by blocking different steps of the human immunodeficiency virus (HIV) replication …
of defense by blocking different steps of the human immunodeficiency virus (HIV) replication …
Cross-talk between SUMOylation and ISGylation in response to interferon
F El-Asmi, FP McManus, CE Brantis-de-Carvalho… - Cytokine, 2020 - Elsevier
Interferon (IFN) plays a central role in regulating host immune response to viral pathogens
through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular …
through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular …
SAMHD1 as the potential link between SARS-CoV-2 infection and neurological complications
The recent pandemic of coronavirus infectious illness 2019 (COVID19) triggered by SARS-
CoV-2 has rapidly spread around the globe, generating in severe events an acute, highly …
CoV-2 has rapidly spread around the globe, generating in severe events an acute, highly …
Host restriction factors modulating HIV latency and replication in macrophages
I Pagani, P Demela, S Ghezzi, E Vicenzi… - International Journal of …, 2022 - mdpi.com
In addition to CD4+ T lymphocytes, myeloid cells and, particularly, differentiated
macrophages are targets of human immunodeficiency virus type-1 (HIV-1) infection via the …
macrophages are targets of human immunodeficiency virus type-1 (HIV-1) infection via the …
Host Cell Restriction Factors Blocking Efficient Vector Transduction: Challenges in Lentiviral and Adeno-Associated Vector Based Gene Therapies
AS Coroadinha - Cells, 2023 - mdpi.com
Gene therapy relies on the delivery of genetic material to the patient's cells in order to
provide a therapeutic treatment. Two of the currently most used and efficient delivery …
provide a therapeutic treatment. Two of the currently most used and efficient delivery …