Amyotrophic lateral sclerosis: translating genetic discoveries into therapies

F Akçimen, ER Lopez, JE Landers, A Nath… - Nature Reviews …, 2023 - nature.com
Recent advances in sequencing technologies and collaborative efforts have led to
substantial progress in identifying the genetic causes of amyotrophic lateral sclerosis (ALS) …

[HTML][HTML] Human endogenous retrovirus K (HML-2) in health and disease

B Xue, LA Sechi, DJ Kelvin - Frontiers in microbiology, 2020 - frontiersin.org
Human endogenous retroviruses (HERVs) are derived from exogenous retrovirus infections
in the evolution of primates and account for about 8% of the human genome. They were …

[HTML][HTML] Resurrection of endogenous retroviruses during aging reinforces senescence

X Liu, Z Liu, Z Wu, J Ren, Y Fan, L Sun, G Cao, Y Niu… - Cell, 2023 - cell.com
Whether and how certain transposable elements with viral origins, such as endogenous
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …

[HTML][HTML] Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma

AH Shah, SR Rivas, TT Doucet-O'Hare… - The Journal of …, 2023 - Am Soc Clin Investig
Human endogenous retroviruses (HERVs) are ancestral viral relics that constitute nearly 8%
of the human genome. Although normally silenced, the most recently integrated provirus …

[HTML][HTML] Saliva antibody-fingerprint of reactivated latent viruses after mild/asymptomatic COVID-19 is unique in patients with myalgic-encephalomyelitis/chronic fatigue …

E Apostolou, M Rizwan, P Moustardas… - Frontiers in …, 2022 - frontiersin.org
Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic
disease considered to be triggered by viral infections in a majority of cases. Symptoms …

The healthy human virome: from virus–host symbiosis to disease

EV Koonin, VV Dolja, M Krupovic - Current opinion in virology, 2021 - Elsevier
Viruses are ubiquitous, essential components of any ecosystem, and of multicellular
organism holobionts. Numerous viruses cause acute infection, killing the host or being …

Blood biomarkers for detection of brain injury in COVID-19 patients

ST DeKosky, PM Kochanek, AB Valadka… - Journal of …, 2021 - liebertpub.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple
organs of coronavirus disease 2019 (COVID-19) patients, including the brain. There are …

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for …

ET Baldwin, M Götte, EP Tchesnokov… - Proceedings of the …, 2022 - National Acad Sciences
Human endogenous retroviruses (HERVs) comprise nearly 8% of the human genome and
are derived from ancient integrations of retroviruses into the germline. The biology of HERVs …

Advances toward curing HIV-1 infection in tissue reservoirs

LJ Henderson, LB Reoma, JA Kovacs, A Nath - Journal of virology, 2020 - Am Soc Microbiol
ABSTRACT A disease of more than 39.6 million people worldwide, HIV-1 infection has no
curative therapy. To date, one man has achieved a sterile cure, with millions more hoping to …

Human endogenous retrovirus K envelope in spinal fluid of amyotrophic lateral sclerosis is toxic

JP Steiner, M Bachani, N Malik, C DeMarino… - Annals of …, 2022 - Wiley Online Library
Objective Human endogenous retroviruses have been implicated in neurodegenerative
diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous …