Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Axons are ultrathin membrane cables that are specialized for the conduction of action
potentials. Although their diameter is variable along their length, how their morphology is …

Recent super-resolution microscopy studies have unveiled a periodic scaffold of actin rings
regularly spaced by spectrins under the plasma membrane of axons. However …

The corporeal beauty of the neuronal cytoskeleton has captured the imagination of
generations of scientists. One of the easiest cellular structures to visualize by light …

Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

The erythrocyte cytoskeleton is a textbook prototype for the submembrane cytoskeleton of
metazoan cells. While early experiments suggest a triangular network of actin-based …

Neurons undergo nanometer-scale deformations during action potentials, and the
underlying mechanism has been actively debated for decades. Previous observations were …

Neuronal activity can be modulated by mechanical stimuli. To study this phenomenon
quantitatively, we mechanically stimulated rat cortical neurons by shear stress and local …

Neuronal axons must navigate a mechanically heterogeneous environment to reach their
targets, but the biophysical mechanisms coupling mechanosensation, growth, and …