The role of oxidative stress in cardiac disease: from physiological response to injury factor

R D'Oria, R Schipani, A Leonardini… - Oxidative medicine …, 2020 - Wiley Online Library
Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …

Molecular basis of cardioprotection: signal transduction in ischemic pre-, post-, and remote conditioning

G Heusch - Circulation research, 2015 - Am Heart Assoc
Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Cardioprotection: nitric oxide, protein kinases, and mitochondria

G Heusch, K Boengler, R Schulz - Circulation, 2008 - Am Heart Assoc
Over the past 2 to 3 decades, several phenomena have been identified that provide
powerful protection against myocardial infarction and other sequelae of …

Loss of cardioprotection with ageing

K Boengler, R Schulz, G Heusch - Cardiovascular research, 2009 - academic.oup.com
Not only the prevalence, but also the mortality due to ischaemic cardiovascular disease is
higher in older than in young humans, and the demographic shift towards an ageing …

A review of soil NO transformation: associated processes and possible physiological significance on organisms

S Medinets, U Skiba, H Rennenberg… - Soil Biology and …, 2015 - Elsevier
NO emissions from soils and ecosystems are of outstanding importance for atmospheric
chemistry. Here we review the current knowledge on processes involved in the formation …

Mitochondrial pathways, permeability transition pore, and redox signaling in cardioprotection: therapeutic implications

C Penna, MG Perrelli, P Pagliaro - Antioxidants & redox signaling, 2013 - liebertpub.com
Reperfusion therapy is the indispensable treatment of acute myocardial infarction (AMI) and
must be applied as soon as possible to attenuate the ischemic insult. However, reperfusion …

The second window of preconditioning (SWOP) where are we now?

DJ Hausenloy, DM Yellon - Cardiovascular drugs and therapy, 2010 - Springer
A standard ischemic preconditioning (IPC) stimulus of one or more brief episodes of non-
lethal myocardial ischemia and reperfusion elicits a bi-phasic pattern of cardioprotection …

Remote ischemic conditioning for stroke: A critical systematic review

H Keevil, BE Phillips… - International Journal of …, 2024 - journals.sagepub.com
Remote ischemic conditioning (RIC) is the application of brief periods of ischemia to an
organ or tissue with the aim of inducing protection from ischemia in a distant organ. It was …

Protective ischaemia in patients: preconditioning and postconditioning

A Granfeldt, DJ Lefer… - Cardiovascular …, 2009 - academic.oup.com
Infarct size can be limited by reducing the determinants of infarct size or increasing collateral
blood flow by treatment initiated before the ischaemic event. Reperfusion is the definitive …

Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans

Z Xia, H Li, MG Irwin - BJA: British Journal of Anaesthesia, 2016 - academic.oup.com
Myocardial ischaemia reperfusion injury is the leading cause of death in patients with
cardiovascular disease. Interventions such as ischaemic pre and postconditioning protect …