The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Abstract γ‐Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central
nervous system. GABA is converted from glutamic acid by the action of glutamic acid …

The dopamine hypothesis of schizophrenia is the principal explanatory model of
antipsychotic drug action. Recent discoveries extend our understanding of the …

Antiepileptic drugs (AEDs) are commonly prescribed for nonepileptic conditions, including
migraine headache, chronic neuropathic pain, mood disorders, schizophrenia and various …

Antiepileptic drugs (AEDs) are used extensively to treat multiple non-epilepsy disorders,
both in neurology and psychiatry. This article provides a review of the clinical efficacy of …

Summary Neuregulin-1 (NRG1), a regulator of neural development, has been shown to
regulate neurotransmission at excitatory synapses. Although ErbB4, a key NRG1 receptor, is …

GABA is the main inhibitory neurotransmitter of the central nervous system (CNS) and one of
the most abundant neurotransmitters in mammals is distributed in most areas of the brain …

Schizophrenia is a chronic, severe, and disabling brain disorder arising from the adverse
interaction of predisposing risk genes and environmental factors. The psychopathology is …

Rationale Activation of “co-agonist” N-methyl-d-aspartate (NMDA) and Glycine B sites is
mandatory for the operation of NMDA receptors, which play an important role in the control …

The clinical interface between psychiatry and neurology is epilepsy; the pharmacological
expression of this interface is antiepileptic drugs (AEDs), as they are used to treat both …