Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this
are multifactorial, although maintaining a growth permissive environment in the distal nerve …

Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone
marrow. Currently MSCs may also be isolated from several alternative sources and they …

The practice of medicine relies on evidence-based clinical research, which prompts clinical
researchers to search for alternative therapeutic modalities that are more efficacious and/or …

Three theories of regeneration dominate neuroscience today, all purporting to explain why
the adult central nervous system (CNS) cannot regenerate. One theory proposes that Nogo …

Natural biomaterials are well positioned to play a significant role in the development of the
next generation of biomaterials for nervous system repair. These materials are derived from …

Peripheral neuropathic pain typically results from trauma-induced nociceptive neuron
hyperexcitability and their spontaneous ectopic activity. This pain persists until the trauma …

Cell-based therapy is a promising treatment to favor tissue healing through less invasive
strategies. Mesenchymal stem cells (MSCs) highlighted as potential candidates due to their …

Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow
mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is …

Acellular nerve grafting is often inferior as well as an inadequate alternative to autografting
for the repair of long gaps in peripheral nerves. Moreover, the injection method is not perfect …

The present study evaluated healing potential of bone marrow-derived mesenchymal stem
cells (BM-MSCs) and BM-MSCs-conditioned medium (BM-MSCs-CM) for acute and …