Techniques for reprogramming somatic cells create new opportunities for drug screening,
disease modeling, artificial organ development, and cell therapy. The development of …

Zinc finger E-box binding homeobox (Zeb) 2 is a transcription factor, identified due its ability
to bind Smad proteins, and consists of multiple functional domains which interact with a …

We have recently demonstrated that reactive glial cells can be directly reprogrammed into
functional neurons by a single neural transcription factor, NeuroD1. Here we report that a …

The first lineage specification of pluripotent mouse epiblast segregates neuroectoderm (NE)
from mesoderm and definitive endoderm (ME) by mechanisms that are not well understood …

Recent studies have demonstrated that human astrocytes and fibroblasts can be directly
converted into functional neurons by small molecules. However, fibroblasts, as a potentially …

Abstract The Autism Spectrum Disorder (ASD) consists of a prevalent and heterogeneous
group of neurodevelopmental diseases representing a severe burden to affected individuals …

Growing evidences have associated Zika virus (ZIKV) infection with congenital
malformations, including microcephaly. Nonetheless, signaling mechanisms that promote …

Neurons are believed to be non-proliferating cells. However, neuronal stem cells are still
present in certain areas of the adult brain, although their proliferation diminishes with age …

The cerebral cortex is composed of billions of morphologically and functionally distinct
neurons. These neurons are produced and organized in a regimental fashion during …

Brain metastases are a devastating consequence of cancer and currently there are no
specific biomarkers or therapeutic targets for risk prediction, diagnosis, and treatment. Here …