The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

X-linked hypophosphataemia (XLH) is the most frequent cause of hypophosphataemia-
associated rickets of genetic origin and is associated with high levels of the phosphaturic …

1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Background X-linked hypophosphatemia is characterized by increased secretion of
fibroblast growth factor 23 (FGF-23), which leads to hypophosphatemia and consequently …

Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate
metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase …

Phosphate is one of the most abundant minerals in the body, and its serum levels are
regulated by a complex set of processes occurring in the intestine, skeleton, and kidneys …

The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1, 25 …

Rickets is a bone disease associated with abnormal serum calcium and phosphate levels.
The clinical presentation is heterogeneous and depends on the age of onset and …

Mineral and bone metabolism are regulated differently in utero compared with the adult. The
fetal kidneys, intestines, and skeleton are not dominant sources of mineral supply for the …

In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …