[HTML][HTML] Oxidative stress in cancer

JD Hayes, AT Dinkova-Kostova, KD Tew - Cancer cell, 2020 - cell.com
Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Reactive oxygen species in the tumor microenvironment: an overview

F Weinberg, N Ramnath, D Nagrath - Cancers, 2019 - mdpi.com
Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of
ROS will determine physiological effects. While high levels of ROS can cause damage to …

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

MC Lampi, CA Reinhart-King - Science translational medicine, 2018 - science.org
Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and
cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical …

[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach… - Redox biology, 2017 - Elsevier
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Structure and mechanisms of ROS generation by NADPH oxidases

F Magnani, A Mattevi - Current opinion in structural biology, 2019 - Elsevier
Highlights•ROS are deliberately produced by the NADPH oxidases in response to specific
physiological stimuli.•The first three-dimensional structure of the NOX catalytic core has …

Reactive oxygen species and cancer: A complex interaction

S Saikolappan, B Kumar, G Shishodia, S Koul, HK Koul - Cancer letters, 2019 - Elsevier
Abstract Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …

[HTML][HTML] Worldwide flavor enhancer monosodium glutamate combined with high lipid diet provokes metabolic alterations and systemic anomalies: An overview

A Banerjee, S Mukherjee, BK Maji - Toxicology Reports, 2021 - Elsevier
In this fast-food era, people depend on ready-made foods and engage in minimal physical
activities that ultimately change their food habits. Majorities of such foods have harmful …

[HTML][HTML] Manganese superoxide dismutase, MnSOD and its mimics

S Miriyala, I Spasojevic, A Tovmasyan… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Increased understanding of the role of mitochondria under physiological and pathological
conditions parallels increased exploration of synthetic and natural compounds able to mimic …

The post-chemotherapy changes of tumor physical microenvironment: targeting extracellular matrix to address chemoresistance

Y Li, G Jin, N Liu, H Guo, F Xu - Cancer Letters, 2024 - Elsevier
The tumor physical microenvironment (TPME) contributes to cancer chemoresistance in both
mechanical and mechanobiological approaches. Along with chemotherapy, the tumor …

'Reverse Warburg effect'of cancer‑associated fibroblasts

L Liang, W Li, X Li, X Jin, Q Liao… - … Journal of Oncology, 2022 - spandidos-publications.com
Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …