Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …

Human cysteine proteases of the papain family have been recognized as potential drug
targets for musculoskeletal diseases. Most of the interest is focused on cathepsins S and K …

It has long been known that very acidic conditions can be found in degenerate discs. The
effect of these acid conditions on matrix turnover are, however, unknown. This study aimed …

Objective To determine and compare the expression of cathepsins K and S proteins in joints
with rheumatoid arthritis (RA) and osteoarthritis (OA) and to determine the effect of …

The degenerative joint disease osteoarthritis (OA) is the most prevalent form of chronic
musculoskeletal disease worldwide, and it commonly afflicts the elderly population. OA …

Articular chondrocytes respond to mechanical forces by alterations in gene expression,
proliferative status, and metabolic functions. Little is known concerning the cell signaling …

Background Recent data have suggested a relationship between acute arthritic pain and
acid sensing ion channel 3 (ASIC3) on primary afferent fibers innervating joints. The …

Disc degeneration is associated with several changes in the physicochemical environment
of intervertebral disc cells. Nucleus pulposus (NP) cells in the center of degenerated discs …

Ascorbic acid has been associated with the slowing of osteoarthritis progression in guinea
pig and man. The goal of this study was to evaluate transcriptional and translational …