Cancer is considered the most important clinical, social and economic issue regarding
cause‑specific disability‑adjusted life years among all human pathologies. Exogenous …

Telomeres play a crucial role in maintaining chromosomal integrity and regulating the
number of cell divisions and have been associated with cellular aging. Telomere length (TL) …

Background/Aim: A small subset of patients with ovarian clear cell carcinoma (OCCC)
harbors telomerase reverse transcriptase promoter (TERTp) mutations. We aimed to analyze …

Abnormal telomerase activity plays a key role in the development of carcinogenesis. The
variants rs2736100 and rs2736098 of the telomerase reverse transcriptase (TERT) gene …

Background Lymphocyte telomere length (LTL)-related genetic variants may modulate LTL
and affect recurrence of squamous cell carcinoma of the oropharynx (SCCOP). Methods A …

Genetic factors underlying lymphocyte telomere length (LTL) may provide insights into
genomic stability and integrity, with direct links to susceptibility to cancer recurrence …

Objective Colorectal cancer is one of the most common malignancy in the world. The
oncogenesis of colorectal cancer is still not fully elucidated. It was reported that microRNA …

Background: Laryngeal cancer is more common in middle-aged and older men. We
conducted an association analysis between ZNF208 polymorphisms and laryngeal cancer …

Currently, the role of cleft-lip and palate transmembrane protein-1-like (CLPTM1L) rs401681
in various tumor types, particularly lung cancer, has garnered significant attention. However …

Tankyrase 是一种多聚ADP 核糖聚合酶, 属于PARP (poly ADP-ribose polymerase) 蛋白家族,
在哺乳动物中有Tankyrase1 和Tankyrase2 两个成员. Tankyrase1 和Tankyrase2 结构相似 …