During meiosis, a programmed induction of DNA double-strand breaks (DSBs) leads to the
exchange of genetic material between homologous chromosomes. These exchanges …

Around 1% of the open reading frames in the human genome encode predicted DNA and
RNA helicases. One highly conserved group of DNA helicases is the RecQ family. Genetic …

The licensing step of DNA double-strand break repair by homologous recombination entails
resection of DNA ends to generate a single-stranded DNA template for assembly of the …

Tudor domain-containing protein 3 (TDRD3) is a major methylarginine effector molecule that
reads methyl-histone marks and facilitates gene transcription. However, the underlying …

Double Holliday junctions (dHJS) are important intermediates of homologous
recombination. The separate junctions can each be cleaved by DNA structure-selective …

The RecQ helicases are conserved from bacteria to humans and play a critical role in
genome stability. In humans, loss of RecQ gene function is associated with cancer …

The Bloom syndrome helicase BLM interacts with topoisomerase IIIα (TOP3A), RMI1 and
RMI2 to form the BTR complex, which dissolves double Holliday junctions to produce non …

A double Holliday junction (dHJ) is a central intermediate of homologous recombination that
can be processed to yield crossover or non-crossover recombination products. To preserve …

The maintenance of genomic stability relies on the coordinated action of a number of cellular
processes, including activation of the DNA-damage checkpoint, DNA replication, DNA …

The RecQ family of DNA helicases is highly conserved throughout evolution, and is
important for the maintenance of genome stability. In humans, five RecQ family members …