Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction

Y Sun, H Shi, S Yin, C Ji, X Zhang, B Zhang, P Wu… - ACS …, 2018 - ACS Publications
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue
regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to …

Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach

A Gomes, P Coelho, R Soares, R Costa - Cell and Tissue Research, 2021 - Springer
The umbilical cord has been proved to be an easy-access, reliable, and useful source of
mesenchymal stem cells (MSC) for clinical applications due to its primitive …

[HTML][HTML] Examining the therapeutic potential of various stem cell sources for differentiation into insulin-producing cells to treat diabetes

G Pan, Y Mu, L Hou, J Liu - Annales d'endocrinologie, 2019 - Elsevier
Novel strategies are being developed to generate stem-cell-derived insulin-producing cells
(IPCs), which could reverse the growing incidence of diabetes worldwide. We reviewed …

Therapeutic efficacy of umbilical cord-derived stem cells for diabetes mellitus: a meta-analysis study

DH Kassem, MM Kamal - Stem Cell Research & Therapy, 2020 - Springer
Background Stem cell therapy provides great hope for patients with diabetes mellitus (DM).
DM is a seriously alarming metabolic disease characterized by hyperglycemia and β cell …

Exendin‐4 enhances osteogenic differentiation of adipose tissue mesenchymal stem cells through the receptor activator of nuclear factor‐kappa B and …

SA Habib, MM Kamal, SA El‐Maraghy… - Journal of Cellular …, 2022 - Wiley Online Library
The capability of mesenchymal stem cells (MSCs) to repair bone damage and defects has
long been investigated. The receptor activator of nuclear factor‐kappa B (RANK), its ligand …

Bone marrow stem cell-derived β-cells: new issue for diabetes cell therapy

HA Aglan, SE Kotob, NS Mahmoud, MS Kishta… - Tissue and Cell, 2024 - Elsevier
This investigation aimed to establish the promising role of insulin-producing cells (IPCs)
growing from bone marrow-mesenchymal stem cells (BM-MSCs) in relieving hyperglycemia …

Molecular mechanism of pancreatic β-cell failure in type 2 diabetes mellitus

H Kaneto, T Kimura, M Shimoda, A Obata, J Sanada… - Biomedicines, 2022 - mdpi.com
Various important transcription factors in the pancreas are involved in the process of
pancreas development, the differentiation of endocrine progenitor cells into mature insulin …

The Effect of Clopidogrel and Ticagrelor on Human Adipose Mesenchymal Stem Cell Osteogenic Differentiation Potential: In Vitro Comparative Study

SS Mohamed, HF Zaki… - … in Pharmacological and …, 2024 - Wiley Online Library
Ticagrelor (TICA) and clopidogrel (CLP) are extensively used antiplatelet drugs that act by
antagonizing the P2Y12 receptors that are found on platelets in addition to bone cells. Aim …

Exendin-4 promotes the vascular smooth muscle cell re-differentiation through AMPK/SIRT1/FOXO3a signaling pathways

Z Liu, M Zhang, T Zhou, Q Shen, X Qin - Atherosclerosis, 2018 - Elsevier
Background and aims The phenotype switching of vascular smooth muscle cells (VSMCs)
plays a key role during development and progression of vascular remodeling diseases …

Characterization of perinatal stem cell spheroids for the development of cell therapy strategy

F Paris, P Marrazzo, V Pizzuti, C Marchionni, M Rossi… - Bioengineering, 2023 - mdpi.com
Type 1 diabetes mellitus (T1DM) is a complex metabolic disease characterized by a massive
loss of insulin-producing cells due to an autoimmune reaction. Currently, daily …