Therapy implications of hepatitis C virus genetic diversity
MA Martinez, S Franco - Viruses, 2020 - mdpi.com
Hepatitis C virus (HCV) is an important human pathogen with a high chronicity rate. An
estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection …
estimated 71 million people worldwide are living with chronic hepatitis C (CHC) infection …
High-throughput sequencing (HTS) for the analysis of viral populations
Abstract The development of High-Throughput Sequencing (HTS) technologies is having a
major impact on the genomic analysis of viral populations. Current HTS platforms can …
major impact on the genomic analysis of viral populations. Current HTS platforms can …
Adaptation of Oxford Nanopore technology for hepatitis C whole genome sequencing and identification of within-host viral variants
Abstract Background Hepatitis C (HCV) and many other RNA viruses exist as rapidly
mutating quasi-species populations in a single infected host. High throughput …
mutating quasi-species populations in a single infected host. High throughput …
Single molecule, near full-length genome sequencing of dengue virus
Current methods for dengue virus (DENV) genome amplification, amplify parts of the
genome in at least 5 overlapping segments and then combine the output to characterize a …
genome in at least 5 overlapping segments and then combine the output to characterize a …
Envelope-specific IgG3 and IgG1 responses are associated with clearance of acute hepatitis C virus infection
MR Walker, AA Eltahla, MM Mina, H Li, AR Lloyd… - Viruses, 2020 - mdpi.com
Hepatitis C virus (HCV) can be cleared naturally in a subset of individuals. However, the
asymptomatic nature of acute HCV infection makes the study of the early immune response …
asymptomatic nature of acute HCV infection makes the study of the early immune response …
Assessing routes of hepatitis C transmission in HIV-infected men who have sex with men using single genome sequencing
H Li, KM Marks, AH Talal, WO van Seggelen, B Akil… - PLoS …, 2020 - journals.plos.org
The epidemic of hepatitis C virus (HCV) infection among HIV-infected men who have sex
with men (MSM) is in its second decade, but the routes of transmission remain poorly …
with men (MSM) is in its second decade, but the routes of transmission remain poorly …
[HTML][HTML] Glecaprevir-pibrentasvir for 4 weeks among people with recent HCV infection: The TARGET3D study
Background & Aims Short duration treatment may aid HCV elimination among key
populations. This study evaluated the efficacy of glecaprevir-pibrentasvir for 4 weeks among …
populations. This study evaluated the efficacy of glecaprevir-pibrentasvir for 4 weeks among …
Validation of variant assembly using HAPHPIPE with Next-Generation sequence data from viruses
Next-generation sequencing (NGS) offers a powerful opportunity to identify low-abundance,
intra-host viral sequence variants, yet the focus of many bioinformatic tools on consensus …
intra-host viral sequence variants, yet the focus of many bioinformatic tools on consensus …
In vitro replicative fitness of early Transmitted founder HIV-1 variants and sensitivity to Interferon alpha
M Ashokkumar, A Sonawane, M Sperk, SP Tripathy… - Scientific reports, 2020 - nature.com
Type I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral
defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the …
defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the …
Testing the genomic stability of the Brazilian yellow fever vaccine strain using next-generation sequencing data
AA Serrão de Andrade, AER Soares… - Interface …, 2021 - royalsocietypublishing.org
The live attenuated yellow fever (YF) vaccine was developed in the 1930s. Currently, the
17D and 17DD attenuated substrains are used for vaccine production. The 17D strain is …
17D and 17DD attenuated substrains are used for vaccine production. The 17D strain is …