Current methods to investigate nociception and pain in zebrafish

N Ohnesorge, C Heinl, L Lewejohann - Frontiers in Neuroscience, 2021 - frontiersin.org
Pain is an unpleasant, negative emotion and its debilitating effects are complex to manage.
Mammalian models have long dominated research on nociception and pain, but there is …

Using the zebrafish lateral line to understand the roles of mitochondria in sensorineural hearing loss

M Holmgren, L Sheets - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Hair cells are the mechanosensory receptors of the inner ear and can be damaged by noise,
aging, and ototoxic drugs. This damage often results in permanent sensorineural hearing …

[HTML][HTML] Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line

AB Coffin, E Dale, E Doppenberg… - Frontiers in Cellular …, 2022 - frontiersin.org
The biomedical community is rapidly developing COVID-19 drugs to bring much-need
therapies to market, with over 900 drugs and drug combinations currently in clinical trials …

Impact of noise on development, physiological stress and behavioural patterns in larval zebrafish

RA Lara, RO Vasconcelos - Scientific Reports, 2021 - nature.com
Noise pollution is increasingly present in aquatic ecosystems, causing detrimental effects on
growth, physiology and behaviour of organisms. However, limited information exists on how …

How zebrafish can drive the future of genetic-based hearing and balance research

L Sheets, M Holmgren, KS Kindt - Journal of the Association for Research …, 2021 - Springer
Over the last several decades, studies in humans and animal models have successfully
identified numerous molecules required for hearing and balance. Many of these studies …

Noise-induced hearing loss in zebrafish model: Characterization of tonotopy and sex-based differences

E Han, DH Lee, S Park, YC Rah, HC Park, JW Choi… - Hearing research, 2022 - Elsevier
Hearing loss caused by frequent and persistent exposure to loud noise is one of the most
common diseases in modern society. Many studies have demonstrated the characteristics of …

Noise-induced hearing loss correlates with inner ear hair cell decrease in larval zebrafish

RA Lara, L Breitzler, IH Lau… - Journal of …, 2022 - journals.biologists.com
Anthropogenic noise can be hazardous for the auditory system and wellbeing of animals,
including humans. However, very limited information is known on how this global …

Transmission disrupted: modeling auditory synaptopathy in zebrafish

KS Kindt, L Sheets - Frontiers in cell and developmental biology, 2018 - frontiersin.org
Sensorineural hearing loss is the most common form of hearing loss in humans, and results
from either dysfunction in hair cells, the sensory receptors of sound, or the neurons that …

Macrophages respond rapidly to ototoxic injury of lateral line hair cells but are not required for hair cell regeneration

ME Warchol, A Schrader, L Sheets - Frontiers in cellular …, 2021 - frontiersin.org
The sensory organs of the inner ear contain resident populations of macrophages, which are
recruited to sites of cellular injury. Such macrophages are known to phagocytose the debris …

Age-related changes in the zebrafish and killifish inner ear and lateral line

AB Coffin, E Dale, O Molano, A Pederson, EK Costa… - Scientific Reports, 2024 - nature.com
Age-related hearing loss (ARHL) is a debilitating disorder for millions worldwide. While there
are multiple underlying causes of ARHL, one common factor is loss of sensory hair cells. In …