LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Long noncoding RNAs: molecular modalities to organismal functions

JL Rinn, HY Chang - Annual review of biochemistry, 2020 - annualreviews.org
We have known for decades that long noncoding RNAs (lncRNAs) can play essential
functions across most forms of life. The maintenance of chromosome length requires an …

The functions and unique features of long intergenic non-coding RNA

JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …

[PDF][PDF] The translational landscape of the human heart

S van Heesch, F Witte, V Schneider-Lunitz, JF Schulz… - Cell, 2019 - cell.com
Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …

Developmental dynamics of lncRNAs across mammalian organs and species

I Sarropoulos, R Marin, M Cardoso-Moreira… - Nature, 2019 - nature.com
Although many long noncoding RNAs (lncRNAs) have been identified in human and other
mammalian genomes, there has been limited systematic functional characterization of these …

Genome-wide analysis of human long noncoding RNAs: a provocative review

CP Ponting, W Haerty - Annual review of genomics and human …, 2022 - annualreviews.org
Do long noncoding RNAs (lncRNAs) contribute little or substantively to human biology? To
address how lncRNA loci and their transcripts, structures, interactions, and functions …

[PDF][PDF] Global positioning system: understanding long noncoding RNAs through subcellular localization

J Carlevaro-Fita, R Johnson - Molecular cell, 2019 - cell.com
The localization of long noncoding RNAs (lncRNAs) within the cell is the primary
determinant of their molecular functions. LncRNAs are often thought of as chromatin …

[HTML][HTML] Purification of cross-linked RNA-protein complexes by phenol-toluol extraction

EC Urdaneta, CH Vieira-Vieira, T Hick… - Nature …, 2019 - nature.com
Recent methodological advances allowed the identification of an increasing number of RNA-
binding proteins (RBPs) and their RNA-binding sites. Most of those methods rely, however …

LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging

Z Yang, S Jiang, J Shang, Y Jiang, Y Dai, B Xu… - Ageing research …, 2019 - Elsevier
Fibrosis is universally observed in multiple aging-related diseases and progressions and is
characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various …

TimeLapse-seq: adding a temporal dimension to RNA sequencing through nucleoside recoding

JA Schofield, EE Duffy, L Kiefer, MC Sullivan… - Nature …, 2018 - nature.com
RNA sequencing (RNA-seq) offers a snapshot of cellular RNA populations, but not temporal
information about the sequenced RNA. Here we report TimeLapse-seq, which uses …