Contributions of age-related thymic involution to immunosenescence and inflammaging

R Thomas, W Wang, DM Su - Immunity & Ageing, 2020 - Springer
Immune system aging is characterized by the paradox of immunosenescence (insufficiency)
and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in …

The integration of inflammaging in age-related diseases

T Fulop, JM Witkowski, F Olivieri, A Larbi - Seminars in immunology, 2018 - Elsevier
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …

The immune system and its dysregulation with aging

L Müller, S Di Benedetto, G Pawelec - … and cell biology of ageing: Part II …, 2019 - Springer
Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation

AL Luo, J Yan, XL Tang, YL Zhao, BY Zhou… - Inflammopharmacology, 2019 - Springer
The aging population is burgeoning globally and this trend presents great challenges to the
current healthcare system as the growing number of aged individuals receives procedures …

[HTML][HTML] The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases

Y Liu, T Yan, JMT Chu, Y Chen, S Dunnett, YS Ho… - Laboratory …, 2019 - Elsevier
Growing evidence has shown the beneficial influence of exercise on humans. Apart from
classic cardioprotection, numerous studies have demonstrated that different exercise …

Immunotherapies for neurodegenerative diseases

I Mortada, R Farah, S Nabha, DM Ojcius… - Frontiers in …, 2021 - frontiersin.org
The current treatments for neurodegenerative diseases are mostly symptomatic without
affecting the underlying cause of disease. Emerging evidence supports a potential role for …

The role of immunosenescence in neurodegenerative diseases

E Costantini, C D'Angelo, M Reale - Mediators of inflammation, 2018 - Wiley Online Library
Aging is characterized by the progressive decline of physiological function and tissue
homeostasis leading to increased vulnerability, degeneration, and death. Aging‐related …

Impact of aging on animal models of Parkinson's disease

IH Klæstrup, MK Just, KL Holm, AKO Alstrup… - Frontiers in aging …, 2022 - frontiersin.org
Aging is the biggest risk factor for developing Parkinson's disease (PD), the second most
common neurodegenerative disorder. Several animal models have been developed to …

Role of peripheral immune cells-mediated inflammation on the process of neurodegenerative diseases

Q Yang, G Wang, F Zhang - Frontiers in Immunology, 2020 - frontiersin.org
Neurodegenerative diseases are characterized by progressive loss of selectively vulnerable
neuronal populations, which contrasts with selectively static loss of neurons due to toxic or …

[HTML][HTML] Immunotherapies for aging-related neurodegenerative diseases—emerging perspectives and new targets

S Kwon, M Iba, C Kim, E Masliah - Neurotherapeutics, 2020 - Elsevier
Neurological disorders such as Alzheimer's disease (AD), Lewy body dementia (LBD),
frontotemporal dementia (FTD), and vascular dementia (VCID) have no disease-modifying …