Astrocyte morphology: Diversity, plasticity, and role in neurological diseases

B Zhou, YX Zuo, RT Jiang - CNS neuroscience & therapeutics, 2019 - Wiley Online Library
Astrocytes are the most abundant glial cells in the central nervous system (CNS) and
participate in synaptic, circuit, and behavioral functions. The well‐developed protoplasmic …

Cellular specificity of NF-κB function in the nervous system

EC Dresselhaus, MK Meffert - Frontiers in immunology, 2019 - frontiersin.org
Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key
functions in a wide array of biological systems. While the role of NF-κB in processes, such as …

[HTML][HTML] The brain as an insulin-sensitive metabolic organ

JL Milstein, HA Ferris - Molecular Metabolism, 2021 - Elsevier
Background The brain was once thought of as an insulin-insensitive organ. We now know
that the insulin receptor is present throughout the brain and serves important functions in …

[HTML][HTML] Hypothalamic astrocytes control systemic glucose metabolism and energy balance

DHM Chao, MK Kirchner, C Pham, E Foppen… - Cell metabolism, 2022 - cell.com
The hypothalamus is key in the control of energy balance. However, strategies targeting
hypothalamic neurons have failed to provide viable options to treat most metabolic diseases …

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

C García-Cáceres, E Balland, V Prevot, S Luquet… - Nature …, 2019 - nature.com
Astrocytes, microglia, and tanycytes play active roles in the regulation of hypothalamic
feeding circuits. These non-neuronal cells are crucial in determining the functional …

The melanocortin pathway and control of appetite-progress and therapeutic implications

G Baldini, KD Phelan - Journal of Endocrinology, 2019 - joe.bioscientifica.com
The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism

V Prevot, B Dehouck, A Sharif, P Ciofi… - Endocrine …, 2018 - academic.oup.com
The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

Inflammation, immunity, and hypertension

DG Harrison, TJ Guzik, HE Lob, MS Madhur… - …, 2011 - Am Heart Assoc
Aprominent pathology textbook used in the United States includes an image illustrating the
renal histopathology caused by malignant hypertension. The legend describes striking …

[HTML][HTML] Green synthesis of silver nanoparticles by Nigella sativa extract alleviates diabetic neuropathy through anti-inflammatory and antioxidant effects

MI Alkhalaf, RH Hussein, A Hamza - Saudi Journal of Biological Sciences, 2020 - Elsevier
Green synthesis of silver nanoparticles has gained great interest among scientists. In view of
this data, we conducted this study to identify the ameliorative effect of green synthesis of …

A closer look at astrocyte morphology: Development, heterogeneity, and plasticity at astrocyte leaflets

B Torres-Ceja, ML Olsen - Current opinion in neurobiology, 2022 - Elsevier
Astrocytes represent an abundant type of glial cell involved in nearly every aspect of central
nervous system (CNS) function, including synapse formation and maturation, ion and …