The relative contribution of cochlear synaptopathy and reduced inhibition to age-related hearing impairment for people with normal audiograms

M Gómez-Álvarez, PT Johannesen… - Trends in …, 2023 - journals.sagepub.com
Older people often show auditory temporal processing deficits and speech-in-noise
intelligibility difficulties even when their audiogram is clinically normal. The causes of such …

[HTML][HTML] The crucial role of diverse animal models to investigate cochlear aging and hearing loss

K Castaño-González, C Köppl, SJ Pyott - Hearing Research, 2024 - Elsevier
Age-related hearing loss affects a large and growing segment of the population, with
profound impacts on quality of life. Age-related pathology of the cochlea—the mammalian …

Cochlear aging disrupts the correlation between spontaneous rate and sound-level coding in auditory nerve fibers

AN Heeringa, F Teske, G Ashida… - Journal of …, 2023 - journals.physiology.org
The spiking activity of auditory nerve fibers (ANFs) transmits information about the acoustic
environment from the cochlea to the central auditory system. Increasing age leads to …

Altered neural encoding of vowels in noise does not affect behavioral vowel discrimination in gerbils with age-related hearing loss

AN Heeringa, C Jüchter, R Beutelmann… - Frontiers in …, 2023 - frontiersin.org
Introduction Understanding speech in a noisy environment, as opposed to speech in quiet,
becomes increasingly more difficult with increasing age. Using the quiet-aged gerbil, we …

Age-related deficits in binaural hearing: Contribution of peripheral and central effects

S Tolnai, M Weiß, R Beutelmann… - Journal of …, 2024 - Soc Neuroscience
Pure-tone audiograms often poorly predict elderly humans' ability to communicate in
everyday complex acoustic scenes. Binaural processing is crucial for discriminating sound …

Cochlear ribbon synapses in aged gerbils

S Bovee, GM Klump, SJ Pyott, C Sielaff… - International Journal of …, 2024 - mdpi.com
In mammalian hearing, type-I afferent auditory nerve fibers comprise the basis of the afferent
auditory pathway. They are connected to inner hair cells of the cochlea via specialized …

Single-unit data for sensory neuroscience: Responses from the auditory nerve of young-adult and aging gerbils

AN Heeringa - Scientific Data, 2024 - nature.com
This dataset was collected to study the functional consequences of age-related hearing loss
for the auditory nerve, which carries acoustic information from the periphery to the central …

Age-related changes in olivocochlear efferent innervation in gerbils

F Steenken, A Pektaş, C Köppl - Frontiers in Synaptic Neuroscience, 2024 - frontiersin.org
Introduction Age-related hearing difficulties have a complex etiology that includes
degenerative processes in the sensory cochlea. The cochlea comprises the start of the …

Conditional ablation of glucocorticoid and mineralocorticoid receptors from cochlear supporting cells reveals their differential roles for hearing sensitivity and dynamics …

CC Barnes, KT Yee, DE Vetter - International Journal of Molecular …, 2023 - mdpi.com
Endogenous glucocorticoids (GC) are known to modulate basic elements of cochlear
physiology. These include both noise-induced injury and circadian rhythms. While GC …

The Stria Vascularis: Renewed Attention on a Key Player in Age-Related Hearing Loss

S Bovee, GM Klump, C Köppl, SJ Pyott - International Journal of …, 2024 - mdpi.com
Age-related hearing loss (HL), or presbycusis, is a complex and heterogeneous condition,
affecting a significant portion of older adults and involving various interacting mechanisms …