Cellular DNA replication is initiated through the action of multiprotein complexes that
recognize replication start sites in the chromosome (termed origins) and facilitate duplex …

The tree of life shows the relationship between all organisms based on their common
ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by …

DNA replication precisely duplicates the genome to ensure stable inheritance of genetic
information. Impaired licensing of origins of replication during the G 1 phase of the cell cycle …

The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in
eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear …

DNA replication licensing is now understood to be the pathway that leads to the assembly of
double hexamers of minichromosome maintenance (Mcm2–7) at origin sites. Cell division …

Cell division cycle protein 45 (Cdc45) is required for DNA synthesis during genome
duplication, as a component of the Cdc45-MCM-GINS (CMG) helicase. Despite its essential …

The resection of DNA strand with a 5´ end at double-strand breaks is an essential step in
recombinational DNA repair. RecJ, a member of DHH family proteins, is the only 5´ nuclease …

Inborn errors of immunity (IEI) occur as the result of inherited monogenic variants that affect
human immune function and lead to immunological disease [1]. More than 500 individual …

Perception of hub genes engaged in metastatic gastric cancer (mGC) promotes novel ways
to diagnose and treat the illness. The goal of this investigation is to recognize the hub genes …

The DNA replication machinery, or replisome, is a macromolecular complex that combines
DNA unwinding, priming and synthesis activities. In eukaryotic cells, the helicase and …