Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Autophagy influences cell survival through maintenance of cell bioenergetics and clearance
of protein aggregates and damaged organelles. Several lines of evidence indicate that …

The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …

The immune system is an evolutionary hallmark of higher organisms that defends the host
against invading pathogens and exogenous infections. This defense includes the …

Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …

Cardiolipin (CL) is a tetra-acylated diphosphatidylglycerol lipid. In physiological conditions,
CL presents unsaturated chains and is located in the inner mitochondria membrane (IMM) …

This work reviews the bio-chemical mechanisms leading to adverse effects produced when
mineral fibres are inhaled and transported in the lungs from the perspective of a …

TLR8 is among the highest-expressed pattern-recognition receptors in the human myeloid
compartment, yet its mode of action is poorly understood. TLR8 engages two distinct ligand …

Aims Pulsed field ablation (PFA), a non-thermal ablative modality, may show different effects
on the myocardial tissue compared to thermal ablation. Thus, this study aimed to compare …