The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

Inferring gene regulatory networks (GRNs) is a fundamental challenge in biology that aims
to unravel the complex relationships between genes and their regulators. Deciphering these …

In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based
on their location within the liver lobule. However, it is unclear whether this spatial variation …

The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

Differential gene expression in response to perturbations is mediated at least in part by
changes in binding of transcription factors (TFs) and other proteins at specific genomic …

Many genes are co‐expressed and form genomic domains of coordinated gene activity.
However, the regulatory determinants of domain co‐activity remain unclear. Here, we …

Enhancers are genomic regions that regulate gene transcription and are located far away
from the transcription start sites of their target genes. Enhancers are highly enriched in …

The question of how metabolism impacts development is seeing a renaissance [,]. How
metabolism exerts instructive signaling functions is one of the central issues that need to be …

Acute myeloid leukemia (AML) is a hematologic malignancy for which allogeneic stem cell
transplantation (alloSCT) often remains the only curative therapeutic approach. However …