Large animal models in regenerative medicine and tissue engineering: to do or not to do

I Ribitsch, PM Baptista, A Lange-Consiglio… - … in Bioengineering and …, 2020 - frontiersin.org
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

A review on the vagus nerve and autonomic nervous system during fetal development: searching for critical windows

F Cerritelli, MG Frasch, MC Antonelli… - Frontiers in …, 2021 - frontiersin.org
The autonomic nervous system (ANS) is one of the main biological systems that regulates
the body's physiology. Autonomic nervous system regulatory capacity begins before birth as …

Translatable mitochondria-targeted protection against programmed cardiovascular dysfunction

KJ Botting, KL Skeffington, Y Niu, BJ Allison… - Science …, 2020 - science.org
The prenatal origins of heart disease in offspring have been established. However, research
in species with developmental milestones comparable to humans is lacking, preventing …

Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging

BS Saini, JRT Darby, S Portnoy, L Sun… - The Journal of …, 2020 - Wiley Online Library
Key points Human fetal Doppler ultrasound and invasive blood gas measurements obtained
by cordocentesis or at the time of delivery reveal similarities with sheep (an extensively used …

A change of heart: understanding the mechanisms regulating cardiac proliferation and metabolism before and after birth

CG Dimasi, JRT Darby… - The Journal of Physiology, 2023 - Wiley Online Library
Mammalian cardiomyocytes undergo major maturational changes in preparation for birth
and postnatal life. Immature cardiomyocytes contribute to cardiac growth via proliferation …

[HTML][HTML] Induced pluripotent stem cells throughout the animal kingdom: availability and applications

LV de Figueiredo Pessôa, FF Bressan… - World Journal of Stem …, 2019 - ncbi.nlm.nih.gov
Up until the mid 2000s, the capacity to generate every cell of an organism was exclusive to
embryonic stem cells. In 2006, researchers Takahashi and Yamanaka developed an …

Cardiorespiratory consequences of intrauterine growth restriction: Influence of timing, severity and duration of hypoxaemia

JRT Darby, TJ Varcoe, S Orgeig, JL Morrison - Theriogenology, 2020 - Elsevier
At birth, weight of the neonate is used as a marker of the 9-month journey as a fetus. Those
neonates born less than the 10th centile for their gestational age are at risk of being …

Organoids to model the endometrium: implantation and beyond

TM Rawlings, K Makwana, M Tryfonos… - Reproduction and …, 2021 - raf.bioscientifica.com
Despite advances in assisted reproductive techniques in the 4 decades since the first
human birth after in vitro fertilisation, 1–2% of couples experience recurrent implantation …

A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues

Z Yan, J Yang, WT Wei, ML Zhou, DX Mo… - Nature …, 2024 - nature.com
High-altitude hypoxia acclimatization requires whole-body physiological regulation in
highland immigrants, but the underlying genetic mechanism has not been clarified. Here we …

Placental MRI predicts fetal oxygenation and growth rates in sheep and human pregnancy

D Flouri, JRT Darby, SL Holman, SKS Cho… - Advanced …, 2022 - Wiley Online Library
Magnetic resonance imaging (MRI) assessment of fetal blood oxygen saturation (SO2) can
transform the clinical management of high‐risk pregnancies affected by fetal growth …