The role of matrix metalloproteinases in the epithelial‐mesenchymal transition of hepatocellular carcinoma

C Scheau, IA Badarau, R Costache… - Analytical cellular …, 2019 - Wiley Online Library
The epithelial‐mesenchymal transition (EMT) is a transformation process mandatory for the
local and distant progression of many malignant tumors, including hepatocellular carcinoma …

Metabolic rearrangements in primary liver cancers: cause and consequences

L Satriano, M Lewinska, PM Rodrigues… - Nature reviews …, 2019 - nature.com
Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …

PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma

K Wang, L Luo, S Fu, M Wang, Z Wang, L Dong… - Nature …, 2023 - nature.com
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in
cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses …

Complex roles of nicotinamide N-methyltransferase in cancer progression

W Wang, C Yang, T Wang, H Deng - Cell Death & Disease, 2022 - nature.com
Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing
the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which …

Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation

J Xiang, C Chen, R Liu, D Gou, L Chang… - The Journal of …, 2021 - Am Soc Clin Investig
Although cancer cells are frequently faced with a nutrient-and oxygen-poor
microenvironment, elevated hexosamine-biosynthesis pathway (HBP) activity and protein O …

HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

Q Xu, Y Li, X Gao, K Kang, JG Williams, L Tong… - Nature …, 2020 - nature.com
Methionine restriction, a dietary regimen that protects against metabolic diseases and aging,
represses cancer growth and improves cancer therapy. However, the response of different …

Glutamine synthetase limits β-catenin–mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1

W Dai, J Shen, J Yan, AJ Bott… - The Journal of …, 2022 - Am Soc Clin Investig
Glutamine synthetase (GS) catalyzes de novo synthesis of glutamine that facilitates cancer
cell growth. In the liver, GS functions next to the urea cycle to remove ammonia waste. As a …

Targeting long chain acyl-CoA synthetases for cancer therapy

M Rossi Sebastiano, G Konstantinidou - International journal of molecular …, 2019 - mdpi.com
The deregulation of cancer cell metabolic networks is now recognized as one of the
hallmarks of cancer. Abnormal lipid synthesis and extracellular lipid uptake are …

Nutrient transporters: connecting cancer metabolism to therapeutic opportunities

ZC Nwosu, MG Song, MP di Magliano, CA Lyssiotis… - Oncogene, 2023 - nature.com
Cancer cells rely on certain extracellular nutrients to sustain their metabolism and growth.
Solute carrier (SLC) transporters enable cells to acquire extracellular nutrients or shuttle …

Identification of a four‐gene metabolic signature predicting overall survival for hepatocellular carcinoma

GM Liu, WX Xie, CY Zhang… - Journal of cellular …, 2020 - Wiley Online Library
While hundreds of consistently altered metabolic genes had been identified in
hepatocellular carcinoma (HCC), the prognostic role of them remains to be further …