Photoelectrochemical biosensor based on BiVO4/Ag2S heterojunction coupled with Exo III-assisted silver nanoclusters amplification for tumor suppressor gene P53

H Li, H Du, D Wu, G Jie - Sensors and Actuators B: Chemical, 2021 - Elsevier
In this work, an innovative photoelectrochemical (PEC) biosensor based on a new BiVO
4/Ag 2 S heterojunction combined with Exo III-assisted silver nanoclusters (NCs) …

A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase

X Lu, J Huang - Communications Biology, 2022 - nature.com
Human γ-secretase cleaves the transmembrane domains (TMDs) of amyloid precursor
protein (APP) into pathologically relevant amyloid-β peptides (Aβs). The detailed …

Computational design of stapled peptide inhibitor against SARS‐CoV‐2 receptor binding domain

AR Choudhury, A Maity, S Chakraborty… - Peptide …, 2022 - Wiley Online Library
Since its first detection in 2019, the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS‐CoV‐2) has been the cause of millions of deaths worldwide. Despite the …

A systematic drug repurposing approach to identify promising inhibitors from FDA-approved drugs against Nsp4 protein of SARS-CoV-2

J Chakraborty, A Maity, H Sarkar - Journal of Biomolecular …, 2023 - Taylor & Francis
COVID-19 is caused by SARS-CoV-2 and responsible for the ongoing global pandemic in
the world. After more than a year, we are still in lurch to combat and control the situation …

Parallel Temperature Replica-Exchange Molecular Dynamics Simulations Capture the Observed Impact of Stapling on Coiled-Coil Conformational Stability

JL Price - The Journal of Physical Chemistry B, 2025 - ACS Publications
Macrocyclization or stapling is an important strategy for increasing the conformational
stability and target-binding affinity of peptides and proteins, especially in therapeutic …

A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2

M Yokomine, J Morimoto, Y Fukuda, T Ueda… - Chemical …, 2024 - pubs.rsc.org
Peptoids are a promising drug modality targeting disease-related proteins, but how a
peptoid engages in protein binding is poorly understood. This is primarily due to a lack of …

Structure-Guided Antiviral Peptides Identification Targeting the HIV-1 Integrase

MS Hossain, MS Alom, MS Kader… - ACS Physical …, 2024 - ACS Publications
HIV-1 integrase (IN), a major protein in the HIV life cycle responsible for integrating viral
cDNA into the host DNA, represents a promising drug target. Small peptides have emerged …

Exploring the Effect of Hydrocarbon Cross‐Linkers on the Structure and Binding of Stapled p53 Peptides

AR Choudhury, V Gaikwad, A Maity… - Proteins: Structure …, 2024 - Wiley Online Library
Short‐length peptides are used as therapeutics due to their high target specificity and low
toxicity; for example, peptides are designed for targeting the interaction between oncogenic …

Dissecting the geometric and hydrophobic constraints of stapled peptides

J Li, YS Tan, CS Verma - Proteins: Structure, Function, and …, 2025 - Wiley Online Library
Stapled peptides are a promising class of molecules with potential as highly specific probes
of protein–protein interactions and as therapeutics. Hydrocarbon stapling affects the peptide …

The Role of Structural Flexibility in Hydrocarbon‐Stapled Peptides Designed to Block Viral Infection via Human ACE2 Mimicry

S Jiang, Y Tian, V Nicolaescu, A Mansurov… - Peptide …, 2024 - Wiley Online Library
The COVID‐19 pandemic drove a uniquely fervent pursuit to explore the potential of peptide,
antibody, protein, and small‐molecule‐based antiviral agents against severe acute …