Postmitotic neurons require persistently active controls to maintain terminal differentiation.
Unlike dividing cells, aberrant cell cycle activation in mature neurons causes apoptosis …

B-type lamins are fundamental components of the nuclear lamina, a complex structure that
acts as a scaffold for organization and function of the nucleus. Lamin B1 and B2, the most …

Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence
suggests that characteristic differences are present in the nuclear mechanics and …

In this study, we explore the dynamic process of colorectal cancer progression, emphasizing
the evolution toward a more metastatic phenotype. The term" evolution" as used in this study …

Telomere maintenance is essential to preserve genomic stability and involves telomere-
specific proteins, DNA replication and repair proteins. Lamins are key components of the …

Abstract C/EBP homologous protein (CHOP) triggers the death of multiple cancers via
endoplasmic reticulum (ER) stress. However, the function and regulatory mechanism of …

Neurodegenerative tauopathies, including Alzheimer's disease, are pathologically defined
by the presence of aggregated forms of tau protein in brains of affected individuals. Previous …

Abnormal nuclear morphology is a hallmark of malignant cells widely used in cancer
diagnosis. Pelger-Huët anomaly (PHA) is a common abnormality of neutrophil nuclear …

The underlying mechanisms by which cellular metabolism affects cervical cancer cell
radiosensitivity remain poorly understood. Here, we found that loss of 3-hydroxy-3 …

The nucleus is the organelle in the cell that contains the genome and its associate proteins
which is collectively called chromatin. New work has shown that chromatin and its …