Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disorder. It is caused
by loss-of-function mutations in the dystrophin gene. Currently, there is no cure. A highly …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

MyoD, a master regulator of myogenesis, exhibits a circadian rhythm in its mRNA and
protein levels, suggesting a possible role in the daily maintenance of muscle phenotype and …

Genetic background significantly affects phenotype in multiple mouse models of human
diseases, including muscular dystrophy. This phenotypic variability is partly attributed to …

Duchenne muscular dystrophy is a severe X-linked hereditary disease caused by the
absence of functional dystrophin. The dystrophin-deficient mdx-mouse strain is a widely …

As a target for gene therapy, Duchenne muscular dystrophy (DMD) presents many obstacles
but also an unparalleled prospect for correction by alternative splicing. The majority of …

Like the ancient Greek hero Hercules, striated muscle is famous for performing impressive
feats of strength. The procurement of food, breathing, and defense or escape from harm all …

Duchenne muscular dystrophy (DMD) is the most common, lethal genetic disorder of
children. A number of animal models of muscular dystrophy exist, but the most effective …