Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Pain results from the activation of a subset of sensory neurones termed nociceptors and has
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …

In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

While chronic pain is considered by some to be a CNS disease, little is understood about
underlying neurobiological mechanisms. Addiction models have heuristic value in this …

A psychotherapeutic regimen that uses alternating bilateral sensory stimulation (ABS) has
been used to treat post-traumatic stress disorder. However, the neural basis that underlies …

Despite the exponential increase in fear research during the last years, few studies have
included female subjects in their design. The need to include females arises from the …

Pathological neural activity in a variety of neurological disorders could be treated by
directing plasticity to specifically renormalize aberrant neural circuits, thereby restoring …

Glutamate is the primary excitatory transmitter of sensory transmission and perception in the
central nervous system. Painful or noxious stimuli from the periphery 'teach'humans and …

Pathological neural activity could be treated by directing specific plasticity to renormalize
circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit …

The poor translational record of pain research has suggested to some observers that
species differences in pain biology might be to blame. In this review, I consider the evidence …