Diabetic kidney disease: from physiology to therapeutics

C Mora‐Fernández… - The Journal of …, 2014 - Wiley Online Library
Diabetic kidney disease (DKD) defines the functional, structural and clinical abnormalities of
the kidneys that are caused by diabetes. This complication has become the single most …

Microalbuminuria as a risk predictor in diabetes: the continuing saga

GL Bakris, M Molitch - Diabetes care, 2014 - Am Diabetes Assoc
OBJECTIVE The rationale for this study was to review the data on microalbuminuria (MA), an
amount of albumin in the urine of 30–299 mg/day, in patients with diabetes in the context of …

Non-proteinuric pathways in loss of renal function in patients with type 2 diabetes

E Porrini, P Ruggenenti, CE Mogensen… - The lancet Diabetes & …, 2015 - thelancet.com
Largely on the basis of data from patients with type 1 diabetes, the natural history of diabetic
renal disease has been classified as a sequence of three stages: normoalbuminuria …

Kidney biopsy in type 2 diabetic patients: critical reflections on present indications and diagnostic alternatives

D Santoro, M Torreggiani, V Pellicanò… - International Journal of …, 2021 - mdpi.com
Roughly 3% of patients worldwide with a new diagnosis of type 2 diabetes mellitus (T2DM)
already have an overt nephropathy at diagnosis and about 20–30% of the remaining ones …

Diabetic nephropathy: is it always there? Assumptions, weaknesses and pitfalls in the diagnosis

K Ioannou - Hormones, 2017 - Springer
Diabetic nephropathy is defined as a microvascular complication of the kidneys induced by
diabetes mellitus and is characterized by albuminuria and progressive loss of kidney …

[HTML][HTML] Diabetic kidney disease: a syndrome rather than a single disease

GB Piccoli, G Grassi, G Cabiddu, M Nazha… - The review of diabetic …, 2015 - ncbi.nlm.nih.gov
The term" diabetic kidney" has recently been proposed to encompass the various lesions,
involving all kidney structures that characterize protean kidney damage in patients with …

MicroRNAs from urinary extracellular vesicles are non-invasive early biomarkers of diabetic nephropathy in type 2 diabetes patients with the 'Asian Indian phenotype'

P Prabu, S Rome, C Sathishkumar, C Gastebois… - Diabetes & …, 2019 - Elsevier
Aims MicroRNAs (miRNAs) from extracellular vesicles (EVs) have been proposed as
promising biomarkers for a number of diseases. In this study, their potential as urine-based …

[HTML][HTML] Evolving spectrum of diabetic nephropathy

J Kopel, C Pena-Hernandez, K Nugent - World journal of diabetes, 2019 - ncbi.nlm.nih.gov
Diabetes remains an important health issue as more patients with chronic and uncontrolled
diabetes develop diabetic nephropathy (DN), which classically presents with proteinuria …

[HTML][HTML] Genome-wide profiling of urinary extracellular vesicle microRNAs associated with diabetic nephropathy in type 1 diabetes

V Ghai, X Wu, A Bheda-Malge, CP Argyropoulos… - Kidney International …, 2018 - Elsevier
Introduction Diabetic nephropathy (DN) is a form of progressive kidney disease that often
leads to end-stage renal disease (ESRD). It is initiated by microvascular complications due …

How to assess diabetic kidney disease progression? From albuminuria to GFR

C García-Carro, A Vergara, S Bermejo… - Journal of Clinical …, 2021 - mdpi.com
Diabetic kidney disease (DKD) is one of the most relevant complications of type 2 diabetes
and dramatically increases the cardiovascular risk in these patients. Currently, DKD is …