Transforming growth factor-β in stem cells and tissue homeostasis

X Xu, L Zheng, Q Yuan, G Zhen, JL Crane, X Zhou… - Bone research, 2018 - nature.com
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …

The role of the TGF-β superfamily in myocardial infarction

A Hanna, NG Frangogiannis - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
The members of the transforming growth factor β (TGF-β) superfamily are essential
regulators of cell differentiation, phenotype and function, and have been implicated in the …

[HTML][HTML] CD36 tango in cancer: signaling pathways and functions

J Wang, Y Li - Theranostics, 2019 - ncbi.nlm.nih.gov
CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake,
immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …

[HTML][HTML] Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis

RM Liu, LP Desai - Redox biology, 2015 - Elsevier
Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …

Into the tissues: Extracellular matrix and its artificial substitutes: Cell signalling mechanisms

A Bandzerewicz, A Gadomska-Gajadhur - Cells, 2022 - mdpi.com
The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

The cytokine TGF-β promotes the development and homeostasis of alveolar macrophages

X Yu, A Buttgereit, I Lelios, SG Utz, D Cansever… - Immunity, 2017 - cell.com
Alveolar macrophages (AMs) derive from fetal liver monocytes, which colonize the lung
during embryonic development and give rise to fully mature AMs perinatally. AM …

Regulation of the bioavailability of TGF-β and TGF-β-related proteins

IB Robertson, DB Rifkin - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
The bioavailability of members of the transforming growth factor β (TGF-β) family is
controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a …

From inflammation to fibrosis—molecular and cellular mechanisms of myocardial tissue remodelling and perspectives on differential treatment opportunities

N Suthahar, WC Meijers, HHW Silljé… - Current heart failure …, 2017 - Springer
Abstract Purpose of Review In this review, we highlight the most important cellular and
molecular mechanisms that contribute to cardiac inflammation and fibrosis. We also discuss …

Extracellular matrix contribution to skin wound re-epithelialization

P Rousselle, M Montmasson, C Garnier - Matrix Biology, 2019 - Elsevier
The ability of skin to act as a barrier is primarily determined by cells that maintain the
continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult …

Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions

I Klaassen, CJF Van Noorden… - Progress in retinal and …, 2013 - Elsevier
Breakdown of the inner endothelial blood-retinal barrier (BRB), as occurs in diabetic
retinopathy, age-related macular degeneration, retinal vein occlusions, uveitis and other …