Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to …
AC Correia, AR Monteiro, R Silva, JN Moreira… - Advanced Drug Delivery …, 2022 - Elsevier
The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …
Pharmacokinetics and pharmacodynamics of intranasal solid lipid nanoparticles and nanostructured lipid carriers for nose-to-brain delivery
TTL Nguyen, HJ Maeng - Pharmaceutics, 2022 - mdpi.com
Nose-to-brain drug delivery has been of great interest for the treatment of many central
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …
nervous system (CNS) diseases and psychiatric disorders over past decades. Several …
[HTML][HTML] Intranasal delivery of Clozapine using nanoemulsion-based in-situ gels: An approach for bioavailability enhancement
NA Abdulla, GF Balata, HA El-Ghamry… - Saudi Pharmaceutical …, 2021 - Elsevier
Limited solubility and hepatic first-pass metabolism are the main causes of low
bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to …
bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to …
Recent progress in nanocarriers for direct nose to brain drug delivery
Nose to brain drug delivery is considered as a viable option to deliver various therapeutic
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …
agents with low cerebral bioavailability bypass blood-brain barrier (BBB). The drug …
Nose to brain delivery of donepezil through surface modified NLCs: Formulation development, optimization, and brain targeting study
M Yasir, A Zafar, KM Noorulla, AJ Tura… - Journal of Drug Delivery …, 2022 - Elsevier
The research was aimed to formulate the Donepezil (DPZ)-loaded nanostructured lipid
carriers (NLCs) and coated with chitosan (CH) for brain targeting through the intranasal …
carriers (NLCs) and coated with chitosan (CH) for brain targeting through the intranasal …
Recent advances in intranasal administration for brain-targeting delivery: a comprehensive review of lipid-based nanoparticles and stimuli-responsive gel formulations
J Koo, C Lim, KT Oh - International Journal of Nanomedicine, 2024 - Taylor & Francis
Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …
Development of atomoxetine-loaded NLC in situ gel for nose-to-brain delivery: optimization, in vitro, and preclinical evaluation
The present study investigates the brain-targeted efficiency of atomoxetine (AXT)-loaded
nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal …
nanostructured lipid carrier (NLC)-laden thermosensitive in situ gel after intranasal …
Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery
AC Correia, JN Moreira, JM Sousa Lobo… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction The nose-to-brain route has been widely investigated to improve drug targeting
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …
Lipid-based nanoparticles via nose-to-brain delivery: A mini review
Y Xinchen, T Jing, G Jiaoqiong - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Central nervous system disorders significantly affect the lives and health of millions of
people worldwide. Despite many therapeutic drugs are available that could potentially target …
people worldwide. Despite many therapeutic drugs are available that could potentially target …
Formulation of intranasal surface engineered nanostructured lipid carriers of rotigotine: Full factorial design optimization, in vitro characterization, and pharmacokinetic …
A Zafar, OA Alsaidan, NK Alruwaili, SS Imam… - International Journal of …, 2022 - Elsevier
The objective of the present research was to develop, optimize, and evaluate rotigotine (RT)-
loaded chitosan (CH) coated nanostructured lipid carriers (RT-CH-NLCs) for nose-to-brain …
loaded chitosan (CH) coated nanostructured lipid carriers (RT-CH-NLCs) for nose-to-brain …