Matrix metalloproteinases: from molecular mechanisms to physiology, pathophysiology, and pharmacology
LGN de Almeida, H Thode, Y Eslambolchi… - Pharmacological …, 2022 - Elsevier
The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …
Comorbid depression in medical diseases
SM Gold, O Köhler-Forsberg, R Moss-Morris… - Nature Reviews …, 2020 - nature.com
Depression is one of the most common comorbidities of many chronic medical diseases
including cancer and cardiovascular, metabolic, inflammatory and neurological disorders …
including cancer and cardiovascular, metabolic, inflammatory and neurological disorders …
Peripheral nerves directly mediate the transneuronal translocation of silver nanomaterials from the gut to central nervous system
The blood circulation is considered the only way for the orally administered nanoparticles to
enter the central nervous systems (CNS), whereas non-blood route-mediated nanoparticle …
enter the central nervous systems (CNS), whereas non-blood route-mediated nanoparticle …
The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective
The physiological consequences of stress often manifest in the gastrointestinal tract.
Traumatic or chronic stress is associated with widespread maladaptive changes throughout …
Traumatic or chronic stress is associated with widespread maladaptive changes throughout …
Animal models of pain: diversity and benefits
C Abboud, A Duveau, R Bouali-Benazzouz… - Journal of neuroscience …, 2021 - Elsevier
Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …
Chronic pancreatitis
Chronic pancreatitis is a multifactorial, fibroinflammatory syndrome in which repetitive
episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting …
episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting …
Antiemetic effects of sclareol, possibly through 5-HT3 and D2 receptor interaction pathways: in-vivo and in-silico studies
Background Emesis is a complex physiological phenomenon that serves as a defense
against numerous toxins, stressful situations, adverse medication responses, chemotherapy …
against numerous toxins, stressful situations, adverse medication responses, chemotherapy …
A transformable mucoadhesive microgel network for noninvasive multimodal imaging and radioprotection of a large area of the gastrointestinal tract
The lack of noninvasive imaging and modulation of a large area of the gastrointestinal (GI)
tract constrain the diagnosis and treatment of many GI‐related diseases. Recent advances …
tract constrain the diagnosis and treatment of many GI‐related diseases. Recent advances …
[HTML][HTML] International consensus guidelines on interventional endoscopy in chronic pancreatitis. Recommendations from the working group for the international …
M Kitano, TM Gress, PK Garg, T Itoi, A Irisawa… - Pancreatology, 2020 - Elsevier
Background/objectives This paper is part of the international consensus guidelines on
chronic pancreatitis, presenting for interventional endoscopy. Methods An international …
chronic pancreatitis, presenting for interventional endoscopy. Methods An international …
Developing nociceptor-selective treatments for acute and chronic pain
Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …
success in treating pain has been limited. Clinically available analgesic agents generally …