Radioactive main group and rare earth metals for imaging and therapy

TI Kostelnik, C Orvig - Chemical reviews, 2018 - ACS Publications
Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

M Srinivasarao, CV Galliford, PS Low - Nature reviews Drug discovery, 2015 - nature.com
Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

Bombesin related peptides/receptors and their promising therapeutic roles in cancer imaging, targeting and treatment

P Moreno, I Ramos-Álvarez, TW Moody… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Despite remarkable advances in tumor treatment, many patients still die from
common tumors (breast, prostate, lung, CNS, colon, and pancreas), and thus, new …

Imaging of tumor hypoxia with radionuclide-labeled tracers for PET

Y Huang, J Fan, Y Li, S Fu, Y Chen, J Wu - Frontiers in Oncology, 2021 - frontiersin.org
The hypoxic state in a solid tumor refers to the internal hypoxic environment that appears as
the tumor volume increases (the maximum radius exceeds 180-200 microns). This state can …

Comparative study of subcutaneous and orthotopic mouse models of prostate cancer: vascular perfusion, vasculature density, hypoxic burden and BB2r-targeting …

W Zhang, W Fan, S Rachagani, Z Zhou, SM Lele… - Scientific reports, 2019 - nature.com
The gastrin-releasing peptide receptor (BB2r) is overexpressed in a variety of cancers
including prostate cancer. As a consequence, the development of BB2r-targeted …

Bombesin-targeted PET of prostate cancer

R Mansi, R Minamimoto, H Mäcke… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Imaging plays an important role in prostate cancer (PC), including accurate evaluation of the
extent of disease, assessment of sites of recurrent disease, and monitoring of response to …

N-terminal modifications improve the receptor affinity and pharmacokinetics of radiolabeled peptidic gastrin-releasing peptide receptor antagonists: examples of 68Ga …

E Gourni, R Mansi, M Jamous, B Waser… - Journal of Nuclear …, 2014 - Soc Nuclear Med
Gastrin-releasing peptide receptors (GRPrs) are overexpressed on a variety of human
cancers, providing the opportunity for peptide receptor targeting via radiolabeled bombesin …

Guiding principles in the design of ligand-targeted nanomedicines

B Wang, CV Galliford, PS Low - Nanomedicine, 2014 - Taylor & Francis
Medicines for the treatment of most human pathologies are encumbered by unwanted side
effects that arise from the deposition of an effective drug into the wrong tissues. The logical …

Bombesin-functionalized superparamagnetic iron oxide nanoparticles for dual-modality MR/NIRFI in mouse models of breast cancer

L Li, C Wu, L Pan, X Li, A Kuang, H Cai… - International Journal of …, 2019 - Taylor & Francis
Background The early and accurate detection afforded by imaging techniques significantly
reduces mortality in cancer patients. However, it is still a great challenge to achieve …

[HTML][HTML] GRPR-targeted protein contrast agents for molecular imaging of receptor expression in cancers by MRI

F Pu, J Qiao, S Xue, H Yang, A Patel, L Wei… - Scientific reports, 2015 - nature.com
Gastrin-releasing peptide receptor (GRPR) is differentially expressed on the surfaces of
various diseased cells, including prostate and lung cancer. However, monitoring temporal …