Dietary habits have drastically changed over the last decades in Western societies. The
Western diet, rich in saturated fatty acids (SFA), trans fatty acids (TFA), omega-6 …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Neurovascular coupling is a critical brain mechanism whereby changes to blood flow
accompany localised neural activity. The breakdown of neurovascular coupling is linked to …

The receptor tyrosine kinase PDGFRβ is essential for pericyte migration to the endothelium.
In mice lacking one allele of PDGFRβ (PDGFRβ+/−), previous reports have described an …

Pericytes are the mural cells of the microvascular network that are in close contact with
underlying endothelial cells. Endothelial-secreted PDGFB leads to recruitment of pericytes …

Altered hypoxia-inducible factor-alpha (HIF-α) activity may have significant consequences in
the hippocampus, which mediates declarative memory, has limited vascularization, and is …

This study was to evaluate the biomechanical characteristics of the vascular wall during
virtual reality‐(VR‐) assisted percutaneous transluminal angioplasty (PTA) and its effect on …

Nutrient delivery to the brain presents a unique challenge because the tissue functions as a
computer system with in the order of 200,000 neurons/mm3. Penetrating arterioles bud from …

Aging is characterized by a progressive loss of cellular functions that increase the risk of
developing chronic diseases, vascular dysfunction, and neurodegenerative conditions. The …

Abstract Background Cardiometabolic diseases (CMDs) increases the risk of cognitive
decline, but the extent to which this can be offset by adherence to an active integrated …